| Autor: |
Sheck EA; Institute of Antimicrobial Chemotherapy (IAC), Smolensk State Medical University (SSMU), Kirova St. 46a, Smolensk 214019, Russia., Edelstein MV; Institute of Antimicrobial Chemotherapy (IAC), Smolensk State Medical University (SSMU), Kirova St. 46a, Smolensk 214019, Russia., Sukhorukova MV; Institute of Antimicrobial Chemotherapy (IAC), Smolensk State Medical University (SSMU), Kirova St. 46a, Smolensk 214019, Russia., Ivanchik NV; Institute of Antimicrobial Chemotherapy (IAC), Smolensk State Medical University (SSMU), Kirova St. 46a, Smolensk 214019, Russia., Skleenova EY; Institute of Antimicrobial Chemotherapy (IAC), Smolensk State Medical University (SSMU), Kirova St. 46a, Smolensk 214019, Russia., Dekhnich AV; Institute of Antimicrobial Chemotherapy (IAC), Smolensk State Medical University (SSMU), Kirova St. 46a, Smolensk 214019, Russia., Azizov IS; Institute of Antimicrobial Chemotherapy (IAC), Smolensk State Medical University (SSMU), Kirova St. 46a, Smolensk 214019, Russia., Kozlov RS; Institute of Antimicrobial Chemotherapy (IAC), Smolensk State Medical University (SSMU), Kirova St. 46a, Smolensk 214019, Russia. |
| Abstrakt: |
A high level of resistance to carbapenems in Acinetobacter baumannii strains severely limits therapeutic possibilities. Colistin is the last resort drug against such strains, although the cases of resistance to this drug have become more frequent. This article presents the epidemiological features and genetic diversity of colistin nonsusceptible A. baumannii strains collected as part of a national multicenter epidemiological study of the antibiotic resistance of pathogens of nosocomial infections (MARATHON), which was conducted in 2013-2014 in Russia. A total of 527 A. baumannii isolates were collected, 10 (1.9%) of which were nonsusceptible to colistin. The majority of nonsusceptible A. baumannii isolates to colistin showed resistance to carbapenems and had the genes of the acquired OXA-40-like carbapenemases ( n = 6). In one case, a combination of OXA-23-like + OXA-40-like ( n = 1) genes was identified. One strain had the multidrug-resistant (MDR) phenotype, 6 isolates had extensively drug-resistant (XDR) phenotype, and 3 isolates had pandrug-resistant (PDR) phenotype. Among the colistin nonsusceptible A. baumannii isolates, 6 individual genotypes were identified, most of which belonged to successful international clones (CC92 OXF /CC2 PAS , n = 4; CC944 OXF /ST78 PAS , n = 4; CC109 OXF /CC1 PAS , n = 1). |
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