| Autor: |
Sachs PC; Medical Diagnostic and Translational Sciences, College of Health Science, Old Dominion University, Norfolk, VA 23529 USA., Mollica PA; Medical Diagnostic and Translational Sciences, College of Health Science, Old Dominion University, Norfolk, VA 23529 USA., Bruno RD; Medical Diagnostic and Translational Sciences, College of Health Science, Old Dominion University, Norfolk, VA 23529 USA. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of biological engineering [J Biol Eng] 2017 Nov 16; Vol. 11, pp. 34. Date of Electronic Publication: 2017 Nov 16 (Print Publication: 2017). |
| DOI: |
10.1186/s13036-017-0077-0 |
| Abstrakt: |
The accumulated evidence points to the microenvironment as the primary mediator of cellular fate determination. Comprised of parenchymal cells, stromal cells, structural extracellular matrix proteins, and signaling molecules, the microenvironment is a complex and synergistic edifice that varies tissue to tissue. Furthermore, it has become increasingly clear that the microenvironment plays crucial roles in the establishment and progression of diseases such as cardiovascular disease, neurodegeneration, cancer, and ageing. Here we review the historical perspectives on the microenvironment, and how it has directed current explorations in tissue engineering. By thoroughly understanding the role of the microenvironment, we can begin to correctly manipulate it to prevent and cure diseases through regenerative medicine techniques. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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