Euterpe oleracea Mart. (açaí) seed extract associated with exercise training reduces hepatic steatosis in type 2 diabetic male rats.

Autor: de Bem GF; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., da Costa CA; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., da Silva Cristino Cordeiro V; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., Santos IB; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., de Carvalho LCRM; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., de Andrade Soares R; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., Ribeiro JH; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., de Souza MAV; Department of Chemical Processes, Institute of Chemistry, Rio de Janeiro State University, Rio de Janeiro, Brazil., da Cunha Sousa PJ; Department of Pharmacy, Federal University of Pará, Belém, Pará, Brazil., Ognibene DT; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil., Resende AC; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil. Electronic address: angelaresende.uerj@gmail.com., de Moura RS; Department of Pharmacology, Institute of Biology, Rio de Janeiro State University, Rio de Janeiro, Brazil.
Jazyk: angličtina
Zdroj: The Journal of nutritional biochemistry [J Nutr Biochem] 2018 Feb; Vol. 52, pp. 70-81. Date of Electronic Publication: 2017 Oct 13.
DOI: 10.1016/j.jnutbio.2017.09.021
Abstrakt: Type 2 diabetes mellitus contributes to an increased risk of metabolic and morphological changes in key organs, such as the liver. We aimed to assess the effect of the açaí seed extract (ASE) associated with exercise training on hepatic steatosis induced by high-fat (HF) diet plus streptozotocin (STZ) in rats. Type 2 diabetes was induced by feeding rats with HF diet (55% fat) for 5 weeks, followed by a single low dose of STZ (35 mg/kg i.p.). Control and diabetic groups were subdivided into four groups that were fed with standard chow diet for 4 weeks. Control (C) group was subdivided into Sedentary C, Training C, ASE Sedentary C and ASE Training C. Diabetic (D) group was subdivided into Sedentary D, Training D, ASE Sedentary D and ASE Training D. ASE (200 mg/kg/day) was administered by intragastric gavage, and the exercise training was performed on a treadmill (30 min/day; 5 days/week). Treatment with ASE associated with exercise training reduced the blood glucose (70.2%), total cholesterol (81.2%), aspartate aminotransferase (51.7%) and hepatic triglyceride levels (66.8%) and steatosis (72%) in ASE Training D group compared with the Sedentary D group. ASE associated with exercise training reduced the hepatic lipogenic proteins' expression (77.3%) and increased the antioxidant defense (63.1%), pAMPK expression (70.2%), cholesterol transporters (71.1%) and the pLKB1/LKB1 ratio (57.1%) in type 2 diabetic rats. In conclusion, ASE treatment associated with exercise training protects against hepatic steatosis in diabetic rats by reducing hepatic lipogenesis and increasing antioxidant defense and cholesterol excretion.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE