17β-estradiol locally increases phasic dopamine release in the dorsal striatum.

Autor: Shams WM; Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: waqqas.shams@gmail.com., Cossette MP; Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: mpy_cossette@hotmail.com., Shizgal P; Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: peter.shizgal@concordia.ca., Brake WG; Department of Psychology, Centre for Studies in Behavioral Neurobiology, Concordia University, Montreal, Quebec, H4B 1R6, Canada. Electronic address: wayne.brake@concordia.ca.
Jazyk: angličtina
Zdroj: Neuroscience letters [Neurosci Lett] 2018 Feb 05; Vol. 665, pp. 29-32. Date of Electronic Publication: 2017 Nov 22.
DOI: 10.1016/j.neulet.2017.11.039
Abstrakt: Studies using in vivo microdialysis have shown that 17β-estradiol (E2) increases dopamine (DA) transmission in the dorsal striatum. Both systemic administration of E2 and local infusion into the dorsal striatum rapidly enhance amphetamine-induced DA release. However, it is not known to what degree these effects reflect tonic and/or phasic DA release. It was hypothesized that E2 acts directly within the DS to rapidly increase phasic DA transmission. In urethane-anesthetized (1.5mL/kg) female rats, we used fast-scan cyclic voltammetry to study the effects of E2 on phasic, electrically-evoked release of DA in the dorsal striatum. Rats were ovariectomized and implanted with a silastic tube containing 5% E2 in cholesterol, previously shown to mimic low physiological serum concentrations of∼20-25pg/mL. DA release was evoked every 1min by delivering biphasic electrical stimulation in the substantia nigra. Local infusions of E2 (244.8pg/μl) into the dorsal striatum increased the amplitude of the electrically evoked DA transients. Behaviorally significant stimuli and events trigger phasic release of DA. The present findings predict that E2 would boost such signaling in behaving subjects.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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