Circulating renalase predicts all-cause mortality and renal outcomes in patients with advanced chronic kidney disease.
Autor: | Baek SH; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.; Department of Internal Medicine, Hallym University Dongtan Sacred Heart Hospital, Hwaseong, Korea., Cha RH; Department of Internal Medicine, National Medical Center, Seoul, Korea., Kang SW; Department of Internal Medicine, Yonsei University College of Medicine, Seoul, Korea., Park CW; Department of Internal Medicine, College of Medicine, Seoul St. Mary's Hospital, The Catholic University of Korea, Seoul, Korea., Cha DR; Department of Internal Medicine, Korea University Ansan Hospital, Ansan, Korea., Kim SG; Department of Internal Medicine, Hallym University Sacred Heart Hospital, Anyang, Korea., Yoon SA; Department of Internal Medicine, College of Medicine, Uijeongbu St. Mary's Hospital, The Catholic University of Korea, Uijeongbu, Korea., Kim S; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea., Han SY; Department of Internal Medicine, Inje University Ilsan Paik Hospital, Goyang, Korea., Park JH; Department of Internal Medicine, Konkuk University Medical Center, Seoul, Korea., Chang JH; Department of Internal Medicine, Gachon University Gil Medical Center, Incheon, Korea., Lim CS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.; Department of Internal Medicine, Seoul Metropolitan Government Seoul National University Boramae Medical Center, Seoul, Korea., Kim YS; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea.; Department of Medical Science, Seoul National University Graduate School, Seoul, Korea.; Kidney Research Institute, Seoul National University, Seoul, Korea., Na KY; Department of Internal Medicine, Seoul National University Bundang Hospital, Seongnam, Korea.; Department of Internal Medicine, Seoul National University College of Medicine, Seoul, Korea. |
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Jazyk: | angličtina |
Zdroj: | The Korean journal of internal medicine [Korean J Intern Med] 2019 Jul; Vol. 34 (4), pp. 858-866. Date of Electronic Publication: 2017 Nov 29. |
DOI: | 10.3904/kjim.2017.058 |
Abstrakt: | Background/aims: Patients with chronic kidney disease (CKD) have been found to show markedly increased rates of end-stage renal disease, major adverse cardiovascular and cerebrovascular events (MACCEs), and mortality. Therefore, new biomarkers are required for the early detection of such clinical outcomes in patients with CKD. We aimed to determine whether the level of circulating renalase was associated with CKD progression, MACCEs, and all-cause mortality, using data from a prospective randomized controlled study, Kremezin STudy Against Renal disease progression in Korea (K-STAR; NCT00860431). Methods: A retrospective analysis of the K-STAR data was performed including 383 patients with CKD (mean age, 56.4 years; male/female, 252/131). We measured circulating renalase levels and examined the effects of these levels on clinical outcomes. Results: The mean level of serum renalase was 75.8 ± 34.8 μg/mL. In the multivariable analysis, lower hemoglobin levels, higher serum creatinine levels, and diabetes mellitus were significantly associated with a higher renalase levels. Over the course of a mean follow-up period of 56 months, 25 deaths and 61 MACCEs occurred. Among 322 patients in whom these outcomes were assessed, 137 adverse renal outcomes occurred after a mean follow-up period of 27.8 months. Each 10- μg/mL increase in serum renalase was associated with significantly greater hazards of all-cause mortality and adverse renal outcomes (hazard ratio [HR] = 1.112, p = 0.049; HR = 1.052, p = 0.045). However, serum renalase level was not associated with the rate of MACCEs in patients with CKD. Conclusion: Our results indicated that circulating renalase might be a predictor of mortality and adverse renal outcomes in patients with CKD. |
Databáze: | MEDLINE |
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