Autor: |
Mori D; Department of Pathobiology and Medical Diagnostics, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, 88400, Malaysia., Khanam W; Department of Paediatrics, Institute of Child and Mother Health, Dhaka, 1362, Bangladesh., Sheikh RA; Department of Paediatrics, Institute of Child and Mother Health, Dhaka, 1362, Bangladesh., Tabib SMSB; Department of Pathobiology and Medical Diagnostics, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, 88400, Malaysia., Ikebe E; Department of Microbiology, Faculty of Medicine, Oita University, Yufu, 879-5593, Oita, Japan., Hossain MM; Perdana University Royal College of Surgeons in Ireland School of Medicine, Serdang, 43400, Selangor, Malaysia., Iha H; Department of Microbiology, Faculty of Medicine, Oita University, Yufu, 879-5593, Oita, Japan., Ahmed K; Department of Pathobiology and Medical Diagnostics, Faculty of Medicine and Health Sciences, Universiti Malaysia Sabah, Kota Kinabalu, 88400, Malaysia. ahmed@ums.edu.my. |
Abstrakt: |
Encephalitis causes significant global morbidity and mortality. A large number of viruses cause encephalitis, and their geographic and temporal distributions vary. In many encephalitis cases, the virus cannot be detected, even after extensive testing. This is one challenge in management of the encephalitis patient. Since cytokines are pivotal in any form of inflammation and vary according to the nature of the inflammation, we hypothesized cytokine levels would allow us to discriminate between encephalitis caused by viruses and other aetiologies. This pilot study was conducted in a tertiary care hospital in Dhaka, Bangladesh. Viral detection was performed by polymerase chain reaction using patient cerebrospinal fluid. Acute phase reactants and cytokines were detected in patient serum. Of the 29 biomarkers assessed using the Wilcoxon rank-sum test, only vascular endothelial growth factor (VEGF) was significantly higher (P = 0.0015) in viral-positive compared with virus-negative encephalitis patients. The area under the curve (AUC) for VEGF was 0.82 (95% confidence interval: 0.66-0.98). Serum VEGF may discriminate between virus-positive and virus-negative encephalitis. Further study will be needed to confirm these findings. |