Exploring the functional significance of sterol glycosyltransferase enzymes.

Autor: Singh G; CSIR-National Botanical Research Institute, Lucknow 226001, India., Dhar YV; CSIR-National Botanical Research Institute, Lucknow 226001, India., Asif MH; CSIR-National Botanical Research Institute, Lucknow 226001, India., Misra P; CSIR-National Botanical Research Institute, Lucknow 226001, India. Electronic address: pratibhamisra@nbri.res.in.
Jazyk: angličtina
Zdroj: Progress in lipid research [Prog Lipid Res] 2018 Jan; Vol. 69, pp. 1-10. Date of Electronic Publication: 2017 Nov 21.
DOI: 10.1016/j.plipres.2017.11.001
Abstrakt: Steroidal alkaloids (SAs) are widely synthesized and distributed in plants manifesting as natural produce endowed with potential for medicinal, pesticidal and other high-value usages. Glycosylation of these SAs raises complex and diverse glycosides in plant cells that indeed govern numerous functional aspects. During the glycosylation process of these valuable metabolites, the addition of carbohydrate molecule(s) is catalyzed by enzymes known as sterol glycosyltransferases (SGTs), commonly referred to as UGTs, leading to the production of steryl glycosides (SGs). The ratio of SGs and nonglyco-conjugated SAs are different in different plant species, however, their biosynthesis in the cell is controlled by different environmental factors. The aim of this review is to evaluate the current SGT enzyme research and the functional consequences of glycomodification of SAs on the physiology and plant development, which together are associated with the plant's primary processes. Pharmaceutical, industrial, and other potential uses of saponins have also been discussed and their use in therapeutics has been unveiled by in silico analysis. The field of biotransformation or conversion of nonglycosylated to glycosylated phytosterols by the activity of SGTs, making them soluble, available and more useful for humankind is the new field of interest towards drug therapy.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: