CT dose reduction factors in the thousands using X-ray phase contrast.

Autor: Kitchen MJ; School of Physics and Astronomy, Monash University, Melbourne, 3800, Australia. Marcus.Kitchen@monash.edu., Buckley GA; School of Physics and Astronomy, Monash University, Melbourne, 3800, Australia., Gureyev TE; School of Physics and Astronomy, Monash University, Melbourne, 3800, Australia.; ARC Centre of Excellence in Advanced Molecular Imaging, School of Physics, University of Melbourne, Parkville, 3052, Australia.; School of Science and Technology, University of New England, Armidale, 2351, Australia., Wallace MJ; The Ritchie Centre, Hudson Institute for Medical Research, Melbourne, 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Melbourne, 3800, Australia., Andres-Thio N; School of Engineering, University of Melbourne, Parkville, 3052, Australia.; School of Mathematics and Statistics, University of Melbourne, Parkville, 3052, Australia., Uesugi K; Japan Synchrotron Radiation Research Institute (JASRI/SPring-8), 1-1-1 Kouto, Sayo, Hyogo 679-5198, Japan., Yagi N; Japan Synchrotron Radiation Research Institute (JASRI/SPring-8), 1-1-1 Kouto, Sayo, Hyogo 679-5198, Japan., Hooper SB; The Ritchie Centre, Hudson Institute for Medical Research, Melbourne, 3168, Australia.; Department of Obstetrics and Gynaecology, Monash University, Melbourne, 3800, Australia.
Jazyk: angličtina
Zdroj: Scientific reports [Sci Rep] 2017 Nov 21; Vol. 7 (1), pp. 15953. Date of Electronic Publication: 2017 Nov 21.
DOI: 10.1038/s41598-017-16264-x
Abstrakt: Phase-contrast X-ray imaging can improve the visibility of weakly absorbing objects (e.g. soft tissues) by an order of magnitude or more compared to conventional radiographs. Combining phase retrieval with computed tomography (CT) can increase the signal-to-noise ratio (SNR) by up to two orders of magnitude over conventional CT at the same radiation dose, without loss of image quality. Our experiments reveal that as the radiation dose decreases, the relative improvement in SNR increases. We show that this enhancement can be traded for a reduction in dose greater than the square of the gain in SNR. Upon reducing the dose 300 fold, the phase-retrieved SNR was still up to 9.6 ± 0.2 times larger than the absorption contrast data with spatial resolution in the tens of microns. We show that this theoretically reveals the potential for dose reduction factors in the tens of thousands without loss in image quality, which would have a profound impact on medical and industrial imaging applications.
Databáze: MEDLINE
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