Data on atherosclerosis specific antibody conjugation to nanoemulsions.

Autor: Prévot G; Univ. Bordeaux, INSERM, U1212, CNRS UMR 5320, ARNA, ARN: Régulations Naturelle et Artificielle, ChemBioPharm, F-33000 Bordeaux, France., Duonor-Cérutti M; CNRS UPS3044, Baculovirus et Thérapie, F-30380 Saint-Christol-lès-Alès, France., Larivière M; Univ. Bordeaux, CNRS UMR 5536, CRMSB, Centre de Résonance Magnétique des Systèmes Biologiques, F-33000 Bordeaux, France., Laroche-Traineau J; Univ. Bordeaux, CNRS UMR 5536, CRMSB, Centre de Résonance Magnétique des Systèmes Biologiques, F-33000 Bordeaux, France., Jacobin-Valat MJ; Univ. Bordeaux, CNRS UMR 5536, CRMSB, Centre de Résonance Magnétique des Systèmes Biologiques, F-33000 Bordeaux, France., Barthélémy P; Univ. Bordeaux, INSERM, U1212, CNRS UMR 5320, ARNA, ARN: Régulations Naturelle et Artificielle, ChemBioPharm, F-33000 Bordeaux, France., Clofent-Sanchez G; Univ. Bordeaux, CNRS UMR 5536, CRMSB, Centre de Résonance Magnétique des Systèmes Biologiques, F-33000 Bordeaux, France., Crauste-Manciet S; Univ. Bordeaux, INSERM, U1212, CNRS UMR 5320, ARNA, ARN: Régulations Naturelle et Artificielle, ChemBioPharm, F-33000 Bordeaux, France.
Jazyk: angličtina
Zdroj: Data in brief [Data Brief] 2017 Oct 26; Vol. 15, pp. 824-827. Date of Electronic Publication: 2017 Oct 26 (Print Publication: 2017).
DOI: 10.1016/j.dib.2017.10.058
Abstrakt: This article present data related to the publication entitled "Iron oxide core oil-in-water nanoemulsion as tracer for atherosclerosis MPI and MRI imaging" (Prévot et al., 2017) [1]. Herein we describe the engineering in the baculovirus-insect cell system and purification processes of the human scFv-Fc TEG4-2C antibody, specific of platelets within the atheroma plaque. For molecular targeting purpose, atheroma specific antibody was conjugated to nanoemulsions (NEs) using a heterobifunctional linker (DSPE-PEG-maleimide). Atheroma labelling was assayed by immunochemistry on arterial sections from rabbits.
Databáze: MEDLINE
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