| Autor: |
Shaw J; 1 The Centre: Incorporating Contraception, GUM and HIV Services, Exeter, UK., Saunders JM; 2 HIV & STI Department, 371011 Public Health England , London, UK., Hughes G; 2 HIV & STI Department, 371011 Public Health England , London, UK. |
| Jazyk: |
angličtina |
| Zdroj: |
International journal of STD & AIDS [Int J STD AIDS] 2018 May; Vol. 29 (6), pp. 547-551. Date of Electronic Publication: 2017 Nov 20. |
| DOI: |
10.1177/0956462417742318 |
| Abstrakt: |
Chlamydia trachomatis and Neisseria gonorrhoeae testing guidance recommends extragenital screening with locally validated nucleic acid amplification tests, with anatomical sites tested separately. Evidence supports multi-patient combined aliquot pooled sampling (PS) for population screening; evidence for within-patient PS is sparse. Within-patient PS could be more cost-effective for triple-site testing, but requires distinct clinical pathways and consideration over loss of information to guide risk assessments and treatment. We explored PS attitudes and practices amongst clinicians in England. A cross-sectional web-based survey was distributed to clinical leads of sexual health services throughout England in February 2016. Fifty-two (52/216, 23%) services responded. One service reported current within-patient PS and two were awaiting implementation. Of the 49 services not pooling, five were considering implementation. Concerns raised included the inability to distinguish infection site(s) (36/52, 69%), absence of national guidance (34/52, 65%) and reduced assay performance (18/52, 34%). Only 8/52 (15%) considered the current level of evidence sufficient to support PS, with 40/52 (77%) requesting further validation studies and 39/52 (77%) national guidance. PS was rarely used by respondents to this survey, although the response rate was low. The clinical challenges presented by PS need to be addressed through further development of the evidence base. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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