Frequency of brain MRI abnormalities in neuromyelitis optica spectrum disorder at presentation: A cohort of Latin American patients.

Autor: Carnero Contentti E; Neuroimmunology Unit, Department of Neuroscience, Hospital Alemán, Buenos Aires, Argentina. Electronic address: junior.carnero@hotmail.com., Daccach Marques V; Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of de São Paulo, São Paulo, Brazil., Soto de Castillo I; Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela., Tkachuk V; Neurology Department, Hospital José de San Martin, Buenos Aires, Argentina., Antunes Barreira A; Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of de São Paulo, São Paulo, Brazil., Armas E; Neurology Department, Hospital Universitario de Caracas, Caracas, Venezuela., Chiganer E; Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina., de Aquino Cruz C; Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of de São Paulo, São Paulo, Brazil., Di Pace JL; Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina., Hryb JP; Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina., Lavigne Moreira C; Department of Neurosciences and Behavioral Sciences, Hospital das Clínicas, Ribeirão Preto Medical School, University of de São Paulo, São Paulo, Brazil., Lessa C; Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina., Molina O; Neurology Department, Hospital Universitario de Maracaibo, Maracaibo, Venezuela., Perassolo M; Neurology Department, Hospital Carlos G. Durand, Buenos Aires, Argentina., Soto A; Neurology Department, Hospital Universitario de Caracas, Caracas, Venezuela., Caride A; Neuroimmunology Unit, Department of Neuroscience, Hospital Alemán, Buenos Aires, Argentina.
Jazyk: angličtina
Zdroj: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2018 Jan; Vol. 19, pp. 73-78. Date of Electronic Publication: 2017 Nov 08.
DOI: 10.1016/j.msard.2017.11.004
Abstrakt: Background: Brain magnetic resonance imaging (BMRI) lesions were classically not reported in neuromyelitis optica (NMO). However, BMRI lesions are not uncommon in NMO spectrum disorder (NMOSD) patients.
Objective: To report BMRI characteristic abnormalities (location and configuration) in NMOSD patients at presentation.
Methods: Medical records and BMRI characteristics of 79 patients with NMOSD (during the first documented attack) in Argentina, Brazil and Venezuela were reviewed retrospectively.
Results: BMRI abnormalities were observed in 81.02% of NMOSD patients at presentation. Forty-two patients (53.1%) showed typical-NMOSD abnormalities. We found BMRI abnormalities at presentation in the brainstem/cerebellum (n = 26; 32.9%), optic chiasm (n = 16; 20.2%), area postrema (n = 13; 16.4%), thalamus/hypothalamus (n = 11; 13.9%), corpus callosum (n = 11; 13.9%), periependymal-third ventricle (n = 9; 11.3%), corticospinal tract (n = 7; 8.8%), hemispheric white matter (n = 1; 1.2%) and nonspecific areas (n = 49; 62.03%). Asymptomatic BMRI lesions were more common. The frequency of brain MRI abnormalities did not differ between patients who were positive and negative for aquaporin 4 antibodies at presentation.
Conclusion: Typical brain MRI abnormalities are frequent in NMOSD at disease onset.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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