Interaction between cardiovascular risk factors and body mass index and 10-year incidence of cardiovascular disease, cancer death, and overall mortality.

Autor: Barroso M; REGICOR Study Group - Cardiovascular Epidemiology and Genetics, IMIM-Hospital del Mar Research Institute, Barcelona, Spain; Primary Care Center La Marina and Primary Health Care Research Institute Jordi Gol, Catalan Institute of Health, Barcelona, Spain., Goday A; Parc de Salut Mar, Barcelona, Spain; Consortium for Biomedical Research in Obesity and Nutrition (CIBEROBN), Spain; Departament de Medicina, Universitat Autònoma de Barcelona, Spain., Ramos R; Family Medicine Research Unit and Primary Health Care Research Unit Institute Jordi Gol, Catalan Institute of Health, Girona, Spain; University of Girona, Spain., Marín-Ibañez A; San Jose Norte Health Centre, Zaragoza, Spain., Guembe MJ; Vascular Risk in Navarra Research Group (RIVANA), Health Department, Navarra Government, Pamplona, Spain; Knowledge Planning, Evaluation and Management, Health Department, Navarra Government, Pamplona, Spain., Rigo F; Cardiovascular Group of Balearic Islands (REDIAP-IBSALUT), Palma de Mallorca, Spain., Tormo-Díaz MJ; Murcian Health Department, Murcia, Spain; University of Murcia, Spain; Murcian Institute of Biomedical Research (IMIMB), Murcia, Spain; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Spain., Moreno-Iribas C; Navarre Public Health Institute, Pamplona, Spain; Research Network for Health Services in Chronic Disease (REDISSEC), Pamplona, Spain; Navarra Hospital, IdiSNA-Navarra Institute for Health Research, Pamplona, Spain., Cabré JJ; Primary Care Center Sant Pere Centre and Primary Health Care Research Unit Institute Jordi Gol, Catalan Institute of Health, Reus-Tarragona, Spain., Segura A; Health Science Institute, Department of Health and Social Affairs, Castile - La Mancha Government, Talavera de la Reina, Spain., Baena-Díez JM; REGICOR Study Group - Cardiovascular Epidemiology and Genetics, IMIM-Hospital del Mar Research Institute, Barcelona, Spain; Primary Care Center La Marina and Primary Health Care Research Institute Jordi Gol, Catalan Institute of Health, Barcelona, Spain., de la Cámara AG; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Spain; Clinical Research Department, Hospital 12 Octubre Research Institute, Madrid, Spain., Lapetra J; Consortium for Biomedical Research in Obesity and Nutrition (CIBEROBN), Spain; Department of Family Medicine, Research Unit, Primary Care Division of Seville, Spain., Quesada M; Family Medicine Research Unit and Primary Health Care Research Unit Institute Jordi Gol, Catalan Institute of Health, Girona, Spain., Medrano MJ; Carlos III Health Institute, Madrid, Spain., Berjón J; Vascular Risk in Navarra Research Group (RIVANA), Health Department, Navarra Government, Pamplona, Spain; Navarra Hospital, IdiSNA-Navarra Institute for Health Research, Pamplona, Spain., Frontera G; Cardiovascular Group of Balearic Islands (REDIAP-IBSALUT), Palma de Mallorca, Spain., Gavrila D; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Spain; Health and Consumers Department, Murcia Government, Murcia, Spain., Barricarte A; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Spain; Navarre Public Health Institute, Pamplona, Spain; Research Network for Health Services in Chronic Disease (REDISSEC), Pamplona, Spain., Basora J; Primary Health Care Research Unit Institute Jordi Gol, Catalan Institute of Health, Reus-Tarragona, Spain., García JM; Health Science Institute, Department of Health and Social Affairs, Castile - La Mancha Government, Talavera de la Reina, Spain., García-Lareo M; Primary Care Center La Marina and Primary Health Care Research Institute Jordi Gol, Catalan Institute of Health, Barcelona, Spain., Lora-Pablos D; Consortium for Biomedical Research in Epidemiology and Public Health (CIBERESP), Spain; Clinical Research Department, Hospital 12 Octubre Research Institute, Madrid, Spain., Mayoral E; Consortium for Biomedical Research in Obesity and Nutrition (CIBEROBN), Spain; Diabetes Strategy, Andalusia Health Service, Sevilla, Spain., Grau M; REGICOR Study Group - Cardiovascular Epidemiology and Genetics, IMIM-Hospital del Mar Research Institute, Barcelona, Spain; CIBERCV CIBER de Enfermedades Cardiovasculares, Spain; University of Barcelona, Spain. Electronic address: mgrau@imim.es., Marrugat J; REGICOR Study Group - Cardiovascular Epidemiology and Genetics, IMIM-Hospital del Mar Research Institute, Barcelona, Spain; CIBERCV CIBER de Enfermedades Cardiovasculares, Spain. Electronic address: jmarrugat@imim.es.
Jazyk: angličtina
Zdroj: Preventive medicine [Prev Med] 2018 Feb; Vol. 107, pp. 81-89. Date of Electronic Publication: 2017 Nov 16.
DOI: 10.1016/j.ypmed.2017.11.013
Abstrakt: The effect of above-normal body mass index (BMI) on health outcomes is controversial because it is difficult to distinguish from the effect due to BMI-associated cardiovascular risk factors. The objective was to analyze the impact on 10-year incidence of cardiovascular disease, cancer deaths and overall mortality of the interaction between cardiovascular risk factors and BMI. We conducted a pooled analysis of individual data from 12 Spanish population cohorts with 10-year follow-up. Participants had no previous history of cardiovascular diseases and were 35-79years old at basal examination. Body mass index was measured at baseline being the outcome measures ten-year cardiovascular disease, cancer and overall mortality. Multivariable analyses were adjusted for potential confounders, considering the significant interactions with cardiovascular risk factors. We included 54,446 individuals (46.5% with overweight and 27.8% with obesity). After considering the significant interactions, the 10-year risk of cardiovascular disease was significantly increased in women with overweight and obesity [Hazard Ratio=2.34 (95% confidence interval: 1.19-4.61) and 5.65 (1.54-20.73), respectively]. Overweight and obesity significantly increased the risk of cancer death in women [3.98 (1.53-10.37) and 11.61 (1.93-69.72)]. Finally, obese men had an increased risk of cancer death and overall mortality [1.62 (1.03-2.54) and 1.34 (1.01-1.76), respectively]. In conclusion, overweight and obesity significantly increased the risk of cancer death and of fatal and non-fatal cardiovascular disease in women; whereas obese men had a significantly higher risk of death for all causes and for cancer. Cardiovascular risk factors may act as effect modifiers in these associations.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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