Molecular analysis driven video-assisted thoracic surgery resections in bilateral synchronous lung cancers: from the test tube to the operatory room.

Autor:	Forti Parri SN; Thoracic Surgery Unit, AUSL Bologna, Maggiore-Bellaria Hospital, Bologna, Italy., Bonfanti B; Thoracic Surgery Unit, AUSL Bologna, Maggiore-Bellaria Hospital, Bologna, Italy., Cancellieri A; Pathology Unit, AUSL Bologna, Maggiore Hospital, Bologna, Italy., De Biase D; Department of Pharmacy and Biotechnology (FaBiT), Molecular Diagnostic Unit, AUSL Bologna, University of Bologna, Bologna, Italy., Trisolini R; Interventional Pulmonology Unit, Policlinico Sant'Orsola-Malpighi, Bologna, Italy., Zoboli S; Nuclear Medicine Unit, AUSL Bologna, Maggiore Hospital, Bologna, Italy., Bertolaccini L; Department of Thoracic Surgery, AUSL Romagna Teaching Hospitals, Ravenna, Italy., Solli P; Thoracic Surgery Unit, AUSL Bologna, Maggiore-Bellaria Hospital, Bologna, Italy., Tallini G; Department of Medicine, Molecular Diagnostic Unit, AUSL Bologna, University of Bologna, School of Medicine, Bologna, Italy.
Jazyk:	angličtina
Zdroj:	Annals of translational medicine [Ann Transl Med] 2017 Oct; Vol. 5 (20), pp. 397.
DOI:	10.21037/atm.2017.07.41
Abstrakt:	Synchronous cancers are not such rare clinical conditions. Nevertheless, even after the 8th edition of the TNM classification of the lung cancer, the surgical approach for patients presenting with synchronous bilateral lung cancer is still under debate. The resection of both lesions in the case of synchronous bilateral lung cancer is reasonable, but, on the other hand, is the lobectomy the correct choice in the event of the single primary with a contralateral metastatic lesion? In this case report, we describe how the molecular analysis and the detection of the EGFR, KRAS and TP53 mutations in both tumours have determined in a patient the two tumours as primary and both the right surgical approach. We also discuss how molecular analysis found differences in all the three genes examined in the two lesions and allowed to exclude the clonal nature of the two tumours. In conclusion, genetic studies help to offer a more radical surgical treatment to this patient. Competing Interests: Conflicts of Interest: The authors have no conflicts of interest to declare.
Databáze:	MEDLINE
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