Kinetics of parasite distribution after reinfection with genetically distinct strains of Toxoplasma gondii.

Autor: Costa JGL; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Tavares AT; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Silva DRC; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Pinto LV; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Baraviera RCA; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Noviello MLM; Departamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Arantes RME; Departamento de Patologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil., Vitor RWA; Departamento de Parasitologia, Universidade Federal de Minas Gerais, Belo Horizonte, Minas Gerais, Brazil. Electronic address: ricardovitor@icb.ufmg.br.
Jazyk: angličtina
Zdroj: Experimental parasitology [Exp Parasitol] 2018 Jan; Vol. 184, pp. 22-30. Date of Electronic Publication: 2017 Nov 14.
DOI: 10.1016/j.exppara.2017.11.003
Abstrakt: Recent data shows that prior infection by Toxoplasma gondii does not protect the host from subsequent reinfection even after the development of immunological memory. Although animal models for T. gondii reinfection were proposed after cases of natural human reinfection were described, little is known about the events that occur immediately after challenge. To further understand these events, BALB/c mice were chronically infected with D8 non-virulent strain (genotype ToxoDB#8 BrIII) and challenged with two different virulent strains: EGS (genotype ToxoDB #229) or CH3 strain (genotype ToxoDB #19). Primary infection protected animals from lethal challenge and morbidity was reduced. Reinfection was confirmed by PCR-RFLP, showing differences in the way the parasites spread in challenged animals. Parasites reached the lungs during early infection and a parasitism delay in the intestine was observed in D8+CH3 group. Parasites from challenge strains were not detected in the brain of D8+CH3 and in the intestine and brain of D8+EGS group. Previous infection with D8 strain of T. gondii protected against lethal challenges, but it did not prevent parasite spread to some organs.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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