Functional connectivity during affective mentalizing in criminal offenders with psychotic disorders: Associations with clinical symptoms.

Autor: Harenski CL; The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA. Electronic address: charenski@mrn.org., Calhoun VD; The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA; Department of Electrical and Computer Engineering, University of New Mexico, Albuquerque, NM, USA., Bustillo JR; Department of Psychiatry, University of New Mexico, Albuquerque, NM, USA., Haas BW; University of Georgia, Athens, GA, USA., Decety J; Departments of Psychology and Psychiatry and Behavioral Neuroscience, University of Chicago, Chicago, IL, USA., Harenski KA; The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA., Caldwell MF; Mendota Mental Health Institute, Madison, WI, USA., Van Rybroek GJ; Mendota Mental Health Institute, Madison, WI, USA., Koenigs M; Department of Psychiatry, University of Wisconsin - Madison, Madison, WI, USA., Thornton DM; Sand Ridge Secure Treatment Center, Mauston, WI, USA., Kiehl KA; The Mind Research Network and Lovelace Biomedical and Environmental Research Institute, Albuquerque, NM, USA; Department of Psychology, University of New Mexico, Albuquerque, NM, USA.
Jazyk: angličtina
Zdroj: Psychiatry research. Neuroimaging [Psychiatry Res Neuroimaging] 2018 Jan 30; Vol. 271, pp. 91-99. Date of Electronic Publication: 2017 Nov 06.
DOI: 10.1016/j.pscychresns.2017.11.003
Abstrakt: Psychotic disorders are associated with neurobehavioral impairments in mental state attribution (mentalizing). These impairments are most severe in psychotic patients with elevated symptom levels, particularly negative and cognitive symptoms. There have been few studies of functional connectivity related to mentalizing in psychotic disorders and associations with symptoms. We conducted a functional MRI study of affective mentalizing in individuals with psychotic disorders and varying symptom levels (positive, negative, cognitive). Participants were drawn from an adjudicated inpatient forensic psychiatric population (criminal offenders). Functional MRI scans were acquired using a 32-channel ultra-fast multiband imaging sequence. Mentalizing task performance and functional connectivity were assessed in psychotic criminal offenders (n = 46) and nonpsychotic offenders (n = 41). Temporal coherent brain networks were estimated with group independent component analysis (ICA). Relative to nonpsychotic offenders, psychotic offenders showed impaired task performance and reduced activation in a component comprising the dorsomedial prefrontal cortex, superior temporal gyrus, and ventrolateral prefrontal cortex. Positive and cognitive symptoms were inversely correlated with component activity and task performance. The results are discussed with reference to potential mechanisms underlying impaired social cognition in psychotic disorders and across symptom types.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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