Targeting subchondral bone mesenchymal stem cell activities for intrinsic joint repair in osteoarthritis.

Autor: Ilas DC; Leeds Institute of Rheumatic & Musculoskeletal Medicine, The University of Leeds, Leeds, UK.; Leeds Institute of Rheumatic & Musculoskeletal Medicine, The University of Leeds, Leeds, UK., Churchman SM; NIHR-Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton, Leeds Teaching Hospitals NHS Trust, Leeds, UK.; NIHR-Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton, Leeds Teaching Hospitals NHS Trust, Leeds, UK., McGonagle D; Leeds Institute of Rheumatic & Musculoskeletal Medicine, The University of Leeds, Leeds, UK.; NIHR-Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton, Leeds Teaching Hospitals NHS Trust, Leeds, UK.; Leeds Institute of Rheumatic & Musculoskeletal Medicine, The University of Leeds, Leeds, UK.; NIHR-Leeds Musculoskeletal Biomedical Research Unit, Chapel Allerton, Leeds Teaching Hospitals NHS Trust, Leeds, UK., Jones E; Leeds Institute of Rheumatic & Musculoskeletal Medicine, The University of Leeds, Leeds, UK.; Leeds Institute of Rheumatic & Musculoskeletal Medicine, The University of Leeds, Leeds, UK.
Jazyk: angličtina
Zdroj: Future science OA [Future Sci OA] 2017 Sep 06; Vol. 3 (4), pp. FSO228. Date of Electronic Publication: 2017 Sep 06 (Print Publication: 2017).
DOI: 10.4155/fsoa-2017-0055
Abstrakt: Osteoarthritis (OA) is a common age-related disease with complex pathophysiology. It is characterized by wide-ranging tissue damage and ultimate biomechanical failure of the whole joint. However, signs of tissue adaptation and attempted repair responses are evident in OA-affected osteochondral tissues. Highlighted in this review article is the role of bone-resident mesenchymal stem cells (MSCs) in these bone remodeling responses, and a proposal that targeting MSC activities in OA subchondral bone could represent a novel approach for intrinsic joint regeneration in OA. The development of these therapies will require better understanding of MSC proliferation, migration and differentiation patterns in relation to OA tissue damage and further clarification of the molecular signaling events in these MSCs during disease progression.
Competing Interests: Financial & competing interests disclosure The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties. No writing assistance was utilized in the production of this manuscript.
Databáze: MEDLINE
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