Brain volume in early MS patients with and without IgG oligoclonal bands in CSF.

Autor: Fenu G; Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy. Electronic address: giuseppefenu@unica.it., Lorefice L; Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy., Sechi V; Radiology Unit, Binaghi Hospital, ATS Sardegna, Cagliari, Italy., Loi L; Radiology Unit, Binaghi Hospital, ATS Sardegna, Cagliari, Italy., Contu F; Radiology Unit, Binaghi Hospital, ATS Sardegna, Cagliari, Italy., Cabras F; Radiology Unit, Binaghi Hospital, ATS Sardegna, Cagliari, Italy., Coghe G; Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy., Frau J; Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy., Secci MA; Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy., Melis C; Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy., Schirru L; Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy., Costa G; Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy., Melas V; Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy., Arru M; Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy., Barracciu MA; Radiology Unit, Binaghi Hospital, ATS Sardegna, Cagliari, Italy., Marrosu MG; Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy., Cocco E; Multiple Sclerosis Centre, Binaghi Hospital, ATS Sardegna, Department of Medical Sciences and Public Health, University of Cagliari, Italy.
Jazyk: angličtina
Zdroj: Multiple sclerosis and related disorders [Mult Scler Relat Disord] 2018 Jan; Vol. 19, pp. 55-58. Date of Electronic Publication: 2017 Nov 08.
DOI: 10.1016/j.msard.2017.11.005
Abstrakt: Background: Oligoclonal bands of IgG (OB) are proposed as an early prognostic factor of the disease. Growing attention is directed towards brain volume evaluation as a possible marker of the severity of MS. Previous studies found that MS patients lacking OB have less brain atrophy.
Aim: to evaluate a possible relationship between OB and cerebral volume in a cohort of early MS patients.
Methods: Inclusion criteria were: diagnosis of relapsing-remitting MS; CSF analysis and MRI acquired simultaneously and within 12 months from clinical onset. A total of 15 healthy controls underwent MRI.
Results: In 20 MS patients, CSF analysis did not show OB synthesis (OB negative group). A control group of 25 MS patients in whom OB was detected was also randomly recruited (OB positive group). T test showed a significant difference in NWV between the OB positive and OB negative groups (P value = 0.01), and between the OB positive group and the healthy controls (P value = 0.001). No differences were detected between OB negative group and healthy controls. Multivariable linear regression showed a relationship between NWV and OB synthesis (P value = 0.02) controlling for age, gender, and EDSS.
Conclusions: Our preliminary results suggest that OB positive patients show more atrophy of white matter since early phases of the disease, supporting the role of CSF analysis as a prognostic factor in MS.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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