| Autor: |
Hamel JD; CCVC, PROTEO, Département de chimie, 1045 avenue de la Médecine, Université Laval, Québec, Québec, Canada G1V 0A6. jean-francois.paquin@chm.ulaval.ca., Hayashi T, Cloutier M, Savoie PR, Thibeault O, Beaudoin M, Paquin JF |
| Jazyk: |
angličtina |
| Zdroj: |
Organic & biomolecular chemistry [Org Biomol Chem] 2017 Nov 29; Vol. 15 (46), pp. 9830-9836. |
| DOI: |
10.1039/c7ob02406a |
| Abstrakt: |
Herein, we report a highly regioselective gold-catalyzed formal hydration of propargylic gem-difluorides. Not only does this transformation provide access to versatile fluorinated building blocks that were difficult or hardly possible to access beforehand, but it also represents a rare case of a highly regioselective gold-catalyzed hydroalkoxylation of internal alkynes and puts forward the utility of the difluoromethylene unit as a directing group in catalysis. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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