Rehabilitative Success After Brain Trauma by Augmenting a Subtherapeutic Dose of Environmental Enrichment With Galantamine.

Autor:	de la Tremblaye PB; 1 University of Pittsburgh, Pittsburgh, PA, USA., Wellcome JL; 1 University of Pittsburgh, Pittsburgh, PA, USA., de Witt BW; 1 University of Pittsburgh, Pittsburgh, PA, USA.; 2 Allegheny General Hospital, Pittsburgh, PA, USA., Cheng JP; 1 University of Pittsburgh, Pittsburgh, PA, USA., Skidmore ER; 1 University of Pittsburgh, Pittsburgh, PA, USA., Bondi CO; 1 University of Pittsburgh, Pittsburgh, PA, USA., Kline AE; 1 University of Pittsburgh, Pittsburgh, PA, USA.
Jazyk:	angličtina
Zdroj:	Neurorehabilitation and neural repair [Neurorehabil Neural Repair] 2017 Oct-Nov; Vol. 31 (10-11), pp. 977-985. Date of Electronic Publication: 2017 Nov 12.
DOI:	10.1177/1545968317739999
Abstrakt:	Background: Environmental enrichment (EE) confers benefits after traumatic brain injury (TBI) when provided daily for > 6 hours, but not 2 or 4 hours, which more accurately reflects the daily amount of clinical rehabilitation. The lack of benefit with sub-therapeutic EE suggests that augmentation with galantamine (GAL), which enhances cognition after TBI, may be indicated to confer benefits. Objective: To test the hypothesis that 2 and 4 hours of EE paired with GAL will provide benefits comparable to 24 hours of EE alone. Moreover, all EE groups will perform better than the standard (STD)-housed GAL group. Methods: Anesthetized rats received a TBI or sham injury and then were randomized to receive intraperitoneal injections of GAL (2 mg/kg) or saline vehicle (VEH; 1 mL/kg) beginning 24 hours after surgery and once daily while receiving EE for 2, 4, or 24 hours. Motor and cognitive assessments were conducted on postoperative days 1-5 and 14-19, respectively. Results: Motor function was significantly improved in the TBI + 24-hour EE group versus the TBI + STD + VEH and TBI + STD + GAL groups ( P < .05). Cognitive performance was enhanced in all EE groups as well as in the TBI + STD + GAL versus TBI + STD + VEH ( P < .05). Moreover, the 2- and 4-hour EE groups receiving GAL did not differ from the 24-hour EE group ( P > .05) and performed better than GAL alone ( P < .05). Conclusions: The findings support the hypothesis and have clinical relevance because, often, only brief rehabilitation may be available in the clinic and, thus, augmenting with a pharmacotherapy such as GAL may lead to outcomes that are significantly better than either therapy alone.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu