Cerebrospinal Fluid Proteins as Regulators of Beta-amyloid Aggregation and Toxicity.

Autor: Pate KM; Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison WI 53706 (USA)., Murphy RM; Department of Chemical and Biological Engineering, University of Wisconsin-Madison, 1415 Engineering Drive, Madison WI 53706 (USA).
Jazyk: angličtina
Zdroj: Israel journal of chemistry [Isr J Chem] 2017 Jul; Vol. 57 (7-8), pp. 602-612. Date of Electronic Publication: 2017 Jan 18.
DOI: 10.1002/ijch.201600078
Abstrakt: Amyloid disorders, such as Alzheimer's, are almost invariably late-onset diseases. One defining diagnostic feature of Alzheimer's disease is the deposition of beta-amyloid as extracellular plaques, primarily in the hippocampus. This raises the question: are there natural protective agents that prevent beta-amyloid from depositing, and is it loss of this protection that leads to onset of disease? Proteins in cerebrospinal fluid (CSF) have been suggested to act as just such natural protective agents. Here, we describe some of the early evidence that led to this suggestion, and we discuss, in greater detail, two CSF proteins that have garnered the bulk of the attention.
Databáze: MEDLINE
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