Biomedical applications of glyconanoparticles based on quantum dots.

Autor: Cunha CRA; Departamento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco, Recife, PE, Brazil; Departamento de Bioquímica e Fisiologia, Universidade Federal de Pernambuco, Recife, PE, Brazil; Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Pernambuco, Recife, PE, Brazil., Oliveira ADPR; Departamento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco, Recife, PE, Brazil; Programa de Pós-Graduação em Ciências Biológicas, Universidade Federal de Pernambuco, Recife, PE, Brazil., Firmino TVC; Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brazil; Programa de Pós-Graduação em Biologia Aplicada à Saúde, Universidade Federal de Pernambuco, Recife, PE, Brazil., Tenório DPLA; Departamento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco, Recife, PE, Brazil., Pereira G; Departamento de Química Fundamental, Universidade Federal de Pernambuco, Recife, PE, Brazil., Carvalho LB Jr; Laboratório de Imunopatologia Keizo Asami, Universidade Federal de Pernambuco, Recife, PE, Brazil., Santos BS; Departamento de Ciências Farmacêuticas, Universidade Federal de Pernambuco, Recife, PE, Brazil., Correia MTS; Departamento de Bioquímica e Fisiologia, Universidade Federal de Pernambuco, Recife, PE, Brazil., Fontes A; Departamento de Biofísica e Radiobiologia, Universidade Federal de Pernambuco, Recife, PE, Brazil. Electronic address: adriana.fontes@pq.cnpq.br.
Jazyk: angličtina
Zdroj: Biochimica et biophysica acta. General subjects [Biochim Biophys Acta Gen Subj] 2018 Mar; Vol. 1862 (3), pp. 427-439. Date of Electronic Publication: 2017 Nov 07.
DOI: 10.1016/j.bbagen.2017.11.010
Abstrakt: Background: Quantum dots (QDs) are outstanding nanomaterials of great interest to life sciences. Their conjugation versatility added to unique optical properties, highlight these nanocrystals as very promising fluorescent probes. Among uncountable new nanosystems, in the last years, QDs conjugated to glycans or lectins have aroused a growing attention and their application as a tool to study biological and functional properties has increased.
Scope of Review: This review describes the strategies, reported in the literature, to conjugate QDs to lectins or carbohydrates, providing valuable information for the elaboration, improvement, and application of these nanoconjugates. It also presents the main applications of these nanosystems in glycobiology, such as their potential to study microorganisms, the development of diseases such as cancer, as well as to develop biosensors.
Major Conclusions: The development of glyconanoparticles based on QDs emerged in the last decade. Many works reporting the conjugation of QDs with carbohydrates and lectins have been published, using different strategies and reagents. These bioconjugates enabled studies that are very sensitive and specific, with potential to detect and elucidate the glycocode expressed in various normal or pathologic conditions.
General Significance: Produce a quick reference source over the main advances reached in the glyconanotechnology using QDs as fluorescent probes.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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