The Future of Radiobiology.

Autor: Kirsch DG; Department of Radiation Oncology and Department of Pharmacology and Cancer Biology, Duke University Medical Center, Durham, NC., Diehn M; Department of Radiation Oncology, Stanford Cancer Institute, and Institute for Stem Cell Biology and Regenerative Medicine, Stanford University School of Medicine, Stanford, CA., Kesarwala AH; Radiation Oncology Branch, National Institutes of Health, Bethesda, MD., Maity A; Department of Radiation Oncology Perelman School of Medicine, University of Pennsylvania, Philadelphia, PA., Morgan MA; Department of Radiation Oncology, University of Michigan, Ann Arbor, MI., Schwarz JK; Department of Radiation Oncology, Washington University School of Medicine, St. Louis, MO., Bristow R; Department of Radiation Oncology, Princess Margaret Cancer Center, Toronto, ON, Canada., Demaria S; Department of Radiation Oncology and Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY., Eke I; Radiation Oncology Branch, National Institutes of Health, Bethesda, MD., Griffin RJ; Department of Radiation Oncology, University of Arkansas for Medical Sciences, Little Rock, AR., Haas-Kogan D; Department of Radiation Oncology, Harvard Medical School, Dana-Farber Cancer Institute, Brigham and Women's Hospital, Boston Children's Hospital, Boston, MA., Higgins GS; Department of Oncology, University of Oxford, Oxford, Oxfordshire, UK., Kimmelman AC; Perlmutter Cancer Center and Department of Radiation Oncology, New York University Langone Medical Center, New York, NY., Kimple RJ; Department of Human Oncology, University of Wisconsin School of Medicine and Public Health, Madison, WI., Lombaert IM; Department of Biologic and Materials Sciences, Biointerfaces Institute, School of Dentistry, University of Michigan, Ann Arbor, MI., Ma L; Department of Experimental Radiation Oncology, The University of Texas MD Anderson Cancer Center, Houston, TX., Marples B; Department of Radiation Oncology, University of Miami, Miami, FL., Pajonk F; Department of Radiation Oncology, University of California, Los Angeles, CA., Park CC; David Geffen School of Medicine, University of California, Los Angeles, CA.; Department of Radiation Oncology, Helen Diller Family Comprehensive Cancer Center, University of California, San Francisco, CA., Schaue D; Division of Molecular and Cellular Oncology, University of California, Los Angeles, CA., Tran PT, Willers, Wouters, Bernhard EJ; Radiation Research Program, Division of Cancer Treatment and Diagnosis, National Cancer Institute, National Institutes of Health, Bethesda, MD.
Jazyk: angličtina
Zdroj: Journal of the National Cancer Institute [J Natl Cancer Inst] 2018 Apr 01; Vol. 110 (4), pp. 329-340.
DOI: 10.1093/jnci/djx231
Abstrakt: Innovation and progress in radiation oncology depend on discovery and insights realized through research in radiation biology. Radiobiology research has led to fundamental scientific insights, from the discovery of stem/progenitor cells to the definition of signal transduction pathways activated by ionizing radiation that are now recognized as integral to the DNA damage response (DDR). Radiobiological discoveries are guiding clinical trials that test radiation therapy combined with inhibitors of the DDR kinases DNA-dependent protein kinase (DNA-PK), ataxia telangiectasia mutated (ATM), ataxia telangiectasia related (ATR), and immune or cell cycle checkpoint inhibitors. To maintain scientific and clinical relevance, the field of radiation biology must overcome challenges in research workforce, training, and funding. The National Cancer Institute convened a workshop to discuss the role of radiobiology research and radiation biologists in the future scientific enterprise. Here, we review the discussions of current radiation oncology research approaches and areas of scientific focus considered important for rapid progress in radiation sciences and the continued contribution of radiobiology to radiation oncology and the broader biomedical research community.
Databáze: MEDLINE