Syngeneic and Xenogeneic Transplantations of Mesenchymal Stromal Cells Modify the Production of Reactive Oxygen Species by Blood Mononuclears of Mice.

Autor: Agaeva EV; A. F. Tsyb Medical Radiology Center, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russia. ekagaeva@yandex.ru., Petrov VN; A. F. Tsyb Medical Radiology Center, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russia., Konoplyannikov AG; A. F. Tsyb Medical Radiology Center, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russia., Popovkina OE; A. F. Tsyb Medical Radiology Center, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russia., Lepekhina LA; A. F. Tsyb Medical Radiology Center, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russia., Sayapina EV; A. F. Tsyb Medical Radiology Center, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russia., Semenkova IV; A. F. Tsyb Medical Radiology Center, Affiliated Department of National Medical Research Radiological Center, Ministry of Health of the Russian Federation, Obninsk, Russia.
Jazyk: angličtina
Zdroj: Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Nov; Vol. 164 (1), pp. 80-84. Date of Electronic Publication: 2017 Nov 09.
DOI: 10.1007/s10517-017-3929-1
Abstrakt: In vivo modifying effects of bone marrow mesenchymal stromal cells of humans and laboratory mice on ROS production by mouse blood mononuclears are studied by luminol-dependent zymosan-induced chemiluminescence after syngeneic and xenogeneic transplantation into systemic blood flow. The chemiluminescent activity of mouse blood mononuclears has increased early (1 day) after syngeneic (mouse mesenchymal stromal cells) and xenogeneic (human mesenchymal stromal cells) transplantation. Later, 7-21 days after syngeneic and xenogeneic transplantation, the chemiluminescent activity of mouse mononuclears is suppressed. The probable mechanisms of involvement of the transplanted mesenchymal stromal cells in reprogramming of the blood mononuclear phagocytes from proinflammatory (M1) to anti-inflammatory (M2) phenotype under conditions of their in vivo interactions are discussed; a frequent manifestation of this reprogramming is transition of the phase of activation into inhibition of ROS-producing activity of macrophages.
Databáze: MEDLINE
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