A prospective study comparing whole-body skeletal X-ray survey with 18F-FDG-PET/CT, 18F-NaF-PET/CT and whole-body MRI in the detection of bone lesions in multiple myeloma patients.
| Autor: | Dyrberg E; Copenhagen University Hospital Herlev, Herlev, Denmark.; Copenhagen University Hospital Herlev, Herlev, Denmark., Hendel HW; Copenhagen University Hospital Herlev, Herlev, Denmark., Al-Farra G; Copenhagen University Hospital Herlev, Herlev, Denmark., Balding L; Copenhagen University Hospital Herlev, Herlev, Denmark., Løgager VB; Copenhagen University Hospital Herlev, Herlev, Denmark., Madsen C; Copenhagen University Hospital Herlev, Herlev, Denmark., Thomsen HS; Copenhagen University Hospital Herlev, Herlev, Denmark. |
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| Jazyk: | angličtina |
| Zdroj: | Acta radiologica open [Acta Radiol Open] 2017 Oct 27; Vol. 6 (10), pp. 2058460117738809. Date of Electronic Publication: 2017 Oct 27 (Print Publication: 2017). |
| DOI: | 10.1177/2058460117738809 |
| Abstrakt: | Background: For decades, the most widely used imaging technique for myeloma bone lesions has been a whole-body skeletal X-ray survey (WBXR), but newer promising imaging techniques are evolving. Purpose: To compare WBXR with the advanced imaging techniques 18F-fluorodeoxyglucose (FDG) positron emission tomography (PET)/computed tomography (CT), 18F-sodium fluoride (NaF) PET/CT and whole-body magnetic resonance imaging (WB-MRI) in the detection of myeloma bone lesions. Material and Methods: Fourteen patients with newly diagnosed multiple myeloma were prospectively enrolled. In addition to WBXR, all patients underwent FDG-PET/CT, NaF-PET/CT, and WB-MRI. Experienced specialists performed blinded readings based on predefined anatomical regions and diagnostic criteria. Results: In a region-based analysis, a two-sided ANOVA test showed that the extent of detected skeletal disease depends on the scanning technique ( P < 0.0001). Tukey's multiple comparison test revealed that WB-MRI on average detects significantly more affected regions than WBXR ( P < 0.005), FDG-PET/CT ( P < 0.0001), and NaF-PET/CT ( P < 0.05). In a patient-based analysis, a Cochran's Q test showed that there are no significant differences in the proportion of patients with bone disease detected by the different scanning techniques ( P = 0.23). Determination of intrareader variability resulted in Kappa coefficients corresponding to moderate (FDG-PET/CT) and substantial agreement (WB-MRI, WBXR, NaF-PET/CT). Conclusion: WB-MRI detects on average significantly more body regions indicative of myeloma bone disease compared to WBXR, FDG-PET/CT, and NaF-PET/CT. The lack of significance in the patient-based analysis is most likely due to the small number of study participants. |
| Databáze: | MEDLINE |
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