| Autor: |
Salah Eldin MM; Department of Medical Application of Laser, National Institute of Laser Enhanced Sciences, Giza, Egypt., Sami NA; Department of Medical Application of Laser, National Institute of Laser Enhanced Sciences, Giza, Egypt., Aly DG; Department of Dermatology and Venereology, National Research Centre, Giza, Egypt., Hanafy NS; Department of Dermatology and Venereology, National Research Centre, Giza, Egypt. |
| Jazyk: |
angličtina |
| Zdroj: |
Journal of lasers in medical sciences [J Lasers Med Sci] 2017 Summer; Vol. 8 (3), pp. 123-127. Date of Electronic Publication: 2017 Jun 27. |
| DOI: |
10.15171/jlms.2017.22 |
| Abstrakt: |
Introduction: Recently, the monochromatic excimer light (MEL) of 308 nm wavelength has shown some advantages in comparison to narrow band ultraviolet B (NB-UVB) for the treatment of vitiligo. To histopathologically compare the early effects of NB-UVB and 308-nm MEL phototherapy on vitiliginous patches using H&E and HMB-45. Methods: Thirty subjects with non-segmental vitiligo lesions were treated twice a week for 6 weeks with 308-nm MEL, while NB-UVB was used to treat lesions contra laterally. Skin biopsies were taken from lesional areas before and after 6 weeks of treatment by either modality. It was prepared for light microscopy and immunohistochemical study (HMB-45). This study was performed as a clinical trial (Trial registration: http://www.pactr.org; Identifier: PACTR201705002279419) Results: All lesions before treatment had labeling index (number of pigmented cells/non-pigmented cells) of 0.0 (0%). After treatment the LI for MEL was 4.2 ± 2.6, while for NB-UVB LI it was 0.3 ± 0.7. MEL showed higher statistical significance regarding increase of basal pigmented cells, and significant decrease in vacuolated keratinocytes and basal membrane thickness than NB-UVB. Conclusion: Although NB-UVB is considered as treatment of choice for vitiligo, MEL is acknowledged as an effective treatment modality for vitiliginous lesions that induces more repigmentation than NB-UVB, and more rapidly, as confirmed by our study. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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