Autoimmune Thyroiditis: A Case Control Study on a Sample of Egyptian Type I Diabetic Patients.

Autor:	Bakr HG; Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Salem IM; Department of Internal Medicine, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Meawed TE; Department of Medical Microbiology & Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., Anis RH; Department of Medical Microbiology & Immunology, Faculty of Medicine, Zagazig University, Zagazig, Egypt., El-Hefnawy MH; National Institute of Diabetes & Endocrinology, Cairo, Egypt.
Jazyk:	angličtina
Zdroj:	The Egyptian journal of immunology [Egypt J Immunol] 2017 Jan; Vol. 24 (1), pp. 119-130.
Abstrakt:	Type 1 diabetic patients are vulnerable for autoimmune thyroid disease. The incidence of type I Diabetes in Egypt is 8/100000. Undiagnosed thyroid dysfunction impairs metabolic status and increase cardiovascular risks in diabetic patients. Objectives of the study were to underscore autoimmune thyroiditis and thyroid dysfunction on a sample of Egyptian type I diabetes mellitus. One hundred type 1 diabetic subjects without previously known thyroid diseases and 50 controls were included. Physical examination, HbA1c, thyroid profile (TSH, free T3 and free T4), thyroid ultrasound anti-peroxidase and anti-thyroglobulin antibodies were assessed. Autoimmune thyroiditis was detected in 27 % of the patients, and significantly associated with parental consanguinity, familial autoimmune disease and goiter. It is concluded that autoimmune thyroiditis is evident on laboratory assessment of type 1 diabetic patients who were apparently euthyroid. Screening of type I diabetics for thyroid diseases should be done even in absence of clinical evidence for better glycemic control and to improve long term outcome. (Copyright© by the Egyptian Association of Immunologists.)
Databáze:	MEDLINE
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