RANDOMIZED COMPARISON BETWEEN TWO-HOURLY AND THREE-HOURLY INTRAMUSCULAR TREATMENT WITH 15(S)15 METHYL PGF 2α FOR TERMINATION OF SECOND TRIMESTER PREGNANCY.

Autor: Anjaneyula R, Banerjee SK, Bhattacharya P, Das Gupta S, Devi K, Kanthamani CR, Krishna UR, Padma RA, Raghavan KS
Jazyk: angličtina
Zdroj: Acta obstetricia et gynecologica Scandinavica [Acta Obstet Gynecol Scand] 1988 Jan; Vol. 67 (S145), pp. 37-40.
DOI: 10.1111/aogs.1988.67.s145.37
Abstrakt: In a multicentre trial, intramuscular 15(S)15 methyl PGF 2α (Prostin 15M, Up-john) was tried at 2-hourly and 3-hourly intervals for induction of second trimester abortion. The time schedule was assigned randomly. Eighty-eight patients for 2-hourly schedule and 89 patients for 3-hourly schedule were recruited. Of 2-hourly 83% and of 3-hourly schedule 88.8% of the patients aborted with the treatment. The induction abortion interval was 15.9 hours in 2-hourly and 17.2 hours in 3-hourly schedule. The dose of Prostin 15M was 2.2 mg and 1.7 mg respectively. The incidence of incomplete abortion was 21.9% in 2-hourly and 27.8% in the 3-hourly. The incidence of vomiting was less in the 3-hourly schedule, however, there was no difference in the incidence of diarrhoea.
(1988 Acta Obstet Gynecol Scand.)
Databáze: MEDLINE
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