| Autor: |
Kalitin NN; N. N. Blokhin Russian Cancer Research Center, Ministry of Health of the Russian Federation, Moscow, Russia. f.oskolov@mail.ru., Chernykh YB; M. F. Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russia., Buravtsova IV; M. F. Vladimirsky Moscow Regional Research and Clinical Institute, Moscow, Russia. |
| Jazyk: |
angličtina |
| Zdroj: |
Bulletin of experimental biology and medicine [Bull Exp Biol Med] 2017 Nov; Vol. 164 (1), pp. 90-94. Date of Electronic Publication: 2017 Nov 09. |
| DOI: |
10.1007/s10517-017-3931-7 |
| Abstrakt: |
The expression of retinoic acid nuclear receptor gene RARα and its relationship with expression of APE1, YB-1, and MDR1 genes was studied in bone marrow aspiration biopsy specimens from 22 patients with newly detected multiple myeloma. The expression of RARα directly correlated with the expression of APE1/YB-1/MDR1 pattern genes. Groups differing by expression of RARα exhibited significant differences in the overall survival of patients; concordant and simultaneous changes in the expression of all genes of the APE1/YB-1/MDR1 pattern suggested the level of RARα gene expression as a potential prognostic factor in the pathogenesis of multiple myeloma. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
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