Multiplexing Visual Signals in the Suprachiasmatic Nuclei.
| Autor: | Stinchcombe AR; Department of Mathematics, University of Michigan, 2074 East Hall, 530 Church Street, Ann Arbor, MI 48109-1043, USA., Mouland JW; Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK., Wong KY; Department of Ophthalmology and Visual Sciences, University of Michigan, Ann Arbor, MI 48105, USA; Department of Molecular, Cellular & Developmental Biology, University of Michigan, Ann Arbor, MI 48105, USA., Lucas RJ; Faculty of Biology, Medicine and Health, University of Manchester, Manchester M13 9PT, UK., Forger DB; Department of Mathematics, University of Michigan, 2074 East Hall, 530 Church Street, Ann Arbor, MI 48109-1043, USA; Department of Computational Medicine and Bioinformatics, University of Michigan, Ann Arbor, MI, USA. Electronic address: forger@umich.edu. |
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| Jazyk: | angličtina |
| Zdroj: | Cell reports [Cell Rep] 2017 Nov 07; Vol. 21 (6), pp. 1418-1425. |
| DOI: | 10.1016/j.celrep.2017.10.045 |
| Abstrakt: | The suprachiasmatic nuclei (SCN), the site of the mammalian circadian (daily) pacemaker, contains thousands of interconnected neurons, some of which receive direct retinal input. Here, we study the fast (<1 s) responses of SCN neurons to visual stimuli with a large-scale mathematical model tracking the ionic currents and voltage of all SCN neurons. We reconstruct the SCN network connectivity and reject 99.99% of theoretically possible SCN networks by requiring that the model reproduces experimentally determined receptive fields of SCN neurons. The model shows how the SCN neuronal network can enhance circadian entrainment by sensitizing a population of neurons in the ventral SCN to irradiance. This SCN network also increases the spatial acuity of neurons and increases the accuracy of a simulated subconscious spatial visual task. We hypothesize that much of the fast electrical activity within the SCN is related to the processing of spatial information. (Copyright © 2017 The Author(s). Published by Elsevier Inc. All rights reserved.) |
| Databáze: | MEDLINE |
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