Two Novel Susceptibility Loci for Prostate Cancer in Men of African Ancestry.

Autor:	Conti DV; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Wang K; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Sheng X; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Bensen JT; Department of Epidemiology, University of North Carolina at Chapel Hill, Chapel Hill, NC.; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC., Hazelett DJ; Bioinformatics and Computational Biology Research Center, Biomedical Sciences, Cedars-Sinai Medical Center, Los Angeles, CA., Cook MB; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD., Ingles SA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA., Kittles RA; University of Arizona College of Medicine and University of Arizona Cancer Center, Tucson, AZ., Strom SS; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX., Rybicki BA; Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI., Nemesure B; Department of Preventive Medicine, Stony Brook University, Stony Brook, NY., Isaacs WB; James Buchanan Brady Urological Institute, Johns Hopkins Hospital and Medical Institution, Baltimore, MD., Stanford JL; Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, WA.; Department of Epidemiology, School of Public Health, University of Washington, Seattle, WA., Zheng W; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN., Sanderson M; Department of Family and Community Medicine, Meharry Medical College, Nashville, TN., John EM; California Prevention Institute of California, Fremont, CA.; Department of Health Research and Policy (Epidemiology), Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA., Park JY; Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL., Xu J; Program for Personalized Cancer Care and Department of Surgery, NorthShore University HealthSystem, Evanston, IL., Stevens VL; Epidemiology Research Program, American Cancer Society, Atlanta, GA., Berndt SI; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD., Huff CD; Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, TX., Wang Z; Department of Computational Biology, St. Jude Children's Research Hospital, Memphis, TN., Yeboah ED; University of Ghana Medical School, Accra, Ghana.; Korle Bu Teaching Hospital, Accra, Ghana., Tettey Y; University of Ghana Medical School, Accra, Ghana.; Korle Bu Teaching Hospital, Accra, Ghana., Biritwum RB; University of Ghana Medical School, Accra, Ghana.; Korle Bu Teaching Hospital, Accra, Ghana., Adjei AA; University of Ghana Medical School, Accra, Ghana.; Korle Bu Teaching Hospital, Accra, Ghana., Tay E; University of Ghana Medical School, Accra, Ghana.; Korle Bu Teaching Hospital, Accra, Ghana., Truelove A; Westat, Rockville, MD., Niwa S; Westat, Rockville, MD., Sellers TA; Department of Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL., Yamoah K; Department of Radiation Oncology and Cancer Epidemiology, Moffitt Cancer Center and Research Institute, Tampa, FL., Murphy AB; Department of Urology, Northwestern University, Chicago, IL., Crawford DC; Institute for Computational Biology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH., Gapstur SM; Epidemiology Research Program, American Cancer Society, Atlanta, GA., Bush WS; Institute for Computational Biology, Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH., Aldrich MC; Division of Epidemiology, Department of Thoracic Surgery, Vanderbilt University Medical Center, Nashville, TN., Cussenot O; CeRePP, GRC No. 5 ONCOTYPE-URO, Institut Universitaire de Cancérologie, UPMC Univ Paris 6, Paris, France., Petrovics G; Department of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD., Cullen J; Department of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD., Neslund-Dudas C; Department of Public Health Sciences, Henry Ford Hospital, Detroit, MI., Stern MC; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA., Jarai ZK; The Institute of Cancer Research, Sutton, London, UK., Govindasami K; Oncogenetics Team, The Institute of Cancer Research and Royal Marsden NHS Foundation Trust, Sutton, UK., Chokkalingam AP; School of Public Health, University of California, Berkeley, Berkeley, CA., Hsing AW; Department of Medicine, Stanford Cancer Institute, Stanford University School of Medicine, Stanford, CA., Goodman PJ; SWOG Statistical Center, Fred Hutchinson Cancer Research Center, Seattle, WA., Hoffmann T; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA., Drake BF; Department of Surgery, Division of Public Health Sciences, Washington University School of Medicine, St. Louis, MO., Hu JJ; Sylvester Comprehensive Cancer Center and Department of Public Health Sciences, University of Miami Miller School of Medicine, Miami, FL., Clark PE; Vanderbilt University Medical Center, Nashville, TN., Van Den Eeden SK; Division of Research, Kaiser Permanente Northern California, Oakland, CA., Blanchet P; University Hospital of Pointe-à-Pitre, Guadeloupe.; FWI and Inserm U1085-IRSET, Rennes, France.; French West Indies University, Pointe-à-Pitre, Guadeloupe, FWI., Fowke JH; Department of Medicine and Urologic Surgery, Vanderbilt University Medical Center, Nashville, TN., Casey G; Center for Public Health Genomics, Department of Public Health Sciences, University of Virginia, Charlottesville, VA., Hennis AJM; Department of Preventive Medicine, Stony Brook University, Stony Brook, NY.; Chronic Disease Research Centre and Faculty of Medical Sciences, University of the West Indies, Bridgetown, Barbados., Han Y; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Lubwama A; School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda., Thompson IM Jr; Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX., Leach R; Department of Urology, University of Texas Health Science Center at San Antonio, San Antonio, TX., Easton DF; Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, UK., Schumacher F; Department of Epidemiology and Biostatistics, Case Western Reserve University, Cleveland, OH., Van den Berg DJ; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Gundell SM; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Stram A; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Wan P; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Xia L; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Pooler LC; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA., Mohler JL; Lineberger Comprehensive Cancer Center, University of North Carolina at Chapel Hill, Chapel Hill, NC.; Department of Urology, Roswell Park Cancer Institute, Buffalo, NY., Fontham ETH; School of Public Health, Louisiana State University Health Sciences Center, New Orleans, LA., Smith GJ; Department of Urology, Roswell Park Cancer Institute, Buffalo, NY., Taylor JA; Epigenetic and Stem Cell Biology Laboratory and Epidemiology Branch, National Institute of Environmental Health Sciences, Research Triangle Park, NC., Srivastava S; Department of Surgery, Center for Prostate Disease Research, Uniformed Services University of the Health Sciences, Bethesda, MD., Eeles RA; The Institute of Cancer Research, Sutton, London, UK.; Royal Marsden NHS Foundation Trust, London, UK., Carpten J; Department of Translational Genomics, Keck School of Medicine, University of Southern California, Los Angeles, CA., Kibel AS; Division of Urology, Brigham and Women's Hospital/Dana-Farber Cancer Institute, Boston, MA.; Washington University, St. Louis, MO., Multigner L; Inserm U1085 - IRSET, Rennes, France., Parent ME; INRS-Institut Armand-Frappier, Institut National de la Recherche Scientifique, University of Quebec, Laval, Quebec, Canada (MEP)., Menegaux F; Inserm, Team Cancer-Environment, Center for Research in Epidemiology and Population Health, Université Paris-Saclay, Université Paris-Sud, Villejuif, France., Cancel-Tassin G; CeRePP, GRC No. 5 ONCOTYPE-URO, Institut Universitaire de Cancérologie, UPMC Univ Paris 6, Paris, France., Klein EA; Glickman Urological and Kidney Institute, Cleveland Clinic, Cleveland, OH., Brureau L; University Hospital of Pointe-à-Pitre, Guadeloupe.; FWI and Inserm U1085-IRSET, Rennes, France.; French West Indies University, Pointe-à-Pitre, Guadeloupe, FWI., Stram DO; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA., Watya S; School of Public Health, Makerere University College of Health Sciences, Kampala, Uganda.; Uro Care, Kampala, Uganda., Chanock SJ; Division of Cancer Epidemiology and Genetics, National Cancer Institute, National Institutes of Health, Bethesda, MD., Witte JS; Department of Epidemiology and Biostatistics, University of California, San Francisco, CA.; Institute for Human Genetics, University of California, San Francisco, CA., Blot WJ; Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt University School of Medicine, Nashville, TN., Henderson BE; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA., Haiman CA; Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, CA.; Norris Comprehensive Cancer Center, University of Southern California, Los Angeles, CA.
Jazyk:	angličtina
Zdroj:	Journal of the National Cancer Institute [J Natl Cancer Inst] 2017 Aug 01; Vol. 109 (8).
DOI:	10.1093/jnci/djx084
Abstrakt:	Prostate cancer incidence is 1.6-fold higher in African Americans than in other populations. The risk factors that drive this disparity are unknown and potentially consist of social, environmental, and genetic influences. To investigate the genetic basis of prostate cancer in men of African ancestry, we performed a genome-wide association meta-analysis using two-sided statistical tests in 10 202 case subjects and 10 810 control subjects. We identified novel signals on chromosomes 13q34 and 22q12, with the risk-associated alleles found only in men of African ancestry (13q34: rs75823044, risk allele frequency = 2.2%, odds ratio [OR] = 1.55, 95% confidence interval [CI] = 1.37 to 1.76, P = 6.10 × 10-12; 22q12.1: rs78554043, risk allele frequency = 1.5%, OR = 1.62, 95% CI = 1.39 to 1.89, P = 7.50 × 10-10). At 13q34, the signal is located 5' of the gene IRS2 and 3' of a long noncoding RNA, while at 22q12 the candidate functional allele is a missense variant in the CHEK2 gene. These findings provide further support for the role of ancestry-specific germline variation in contributing to population differences in prostate cancer risk. (© The Author 2017. Published by Oxford University Press.)
Databáze:	MEDLINE
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