Tongue development in stillborns autopsied at different gestational ages.

Autor:	Aguiar LS; Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil., Juliano GR; Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil., Silveira LAM; Universidade Federal do Triângulo Mineiro (UFTM), Departamento de Cirurgia, Programa de Pós-Graduação em Ciências da Saúde, Uberaba, MG, Brazil. Electronic address: drluciano@hotmail.com., Oliveira MS; Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil., Torquato BGS; Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil., Juliano GR; Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil., Araújo MF; Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil., Pereira SAL; Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil., Teixeira VPA; Universidade Federal do Triângulo Mineiro (UFTM), Instituto de Ciências Biológicas e Naturais, Uberaba, MG, Brazil., Ferraz MLF; Universidade Federal do Triângulo Mineiro (UFTM), Uberaba, MG, Brazil.
Jazyk:	angličtina
Zdroj:	Jornal de pediatria [J Pediatr (Rio J)] 2018 Nov - Dec; Vol. 94 (6), pp. 616-623. Date of Electronic Publication: 2017 Nov 04.
DOI:	10.1016/j.jped.2017.08.009
Abstrakt:	Objectives: This study aimed to analyze, through the morphometric method, the perimeter and length of the tongue, the collagen fibers, and the perimeter of blood vessels at different gestational ages and fetal weights. Material and Methods: Tongues (n=55) of stillborns autopsied at 23-40 weeks of gestational age were macroscopically analyzed, and their length and perimeter were measured. Fifty-five tongue fragments were collected through a longitudinal section in the region that accompanies the median lingual sulcus and histologically processed. Slides were stained with picrosirius and immunolabeled with CD31 antibody. Quantification was performed on collagen fibers under polarized light, and on the perimeter of vessels with the CD31. Results: A positive and significant correlation of gestational age with tongue perimeter and length was found. There was a positive and significant correlation between collagen fibers and gestational age, as well as between gestational age and the perimeter of blood vessels. Between collagen fibers and fetal weight, a positive and significant increase was observed. Regarding the correlation between the perimeter of blood vessels and the fetal weight, an increase was observed. Conclusion: As gestational age advances, there is an increase in tongue perimeter and length, in the percentage of collagen fibers, and in vascular perimeter, demonstrating that tongue formation is directly related to tongue growth and development. (Copyright © 2017 Sociedade Brasileira de Pediatria. Published by Elsevier Editora Ltda. All rights reserved.)
Databáze:	MEDLINE
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