Prenatal and early-life triclosan and paraben exposure and allergic outcomes.

Autor: Lee-Sarwar K; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass. Electronic address: klee-sarwar@bwh.harvard.edu., Hauser R; Departments of Environmental Health and Epidemiology, Harvard T. H. Chan School of Public Health, Boston, and Massachusetts General Hospital Fertility Center and Harvard Medical School, Boston, Mass., Calafat AM; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga., Ye X; Division of Laboratory Sciences, National Center for Environmental Health, Centers for Disease Control and Prevention, Atlanta, Ga., O'Connor GT; Pulmonary Center and Department of Medicine, Boston University School of Medicine, Boston, Mass., Sandel M; Department of Pediatrics, Boston Medical Center, Boston, Mass., Bacharier LB; Division of Pediatric Allergy, Immunology and Pulmonary Medicine, Department of Pediatrics, Washington University School of Medicine, and St Louis Children's Hospital, St Louis, Mo., Zeiger RS; Kaiser Permanente Southern California, San Diego, Calif., Laranjo N; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., Gold DR; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., Weiss ST; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., Litonjua AA; Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass., Savage JH; Division of Rheumatology, Immunology and Allergy, Brigham and Women's Hospital and Harvard Medical School, Boston, Mass.
Jazyk: angličtina
Zdroj: The Journal of allergy and clinical immunology [J Allergy Clin Immunol] 2018 Jul; Vol. 142 (1), pp. 269-278.e15. Date of Electronic Publication: 2017 Oct 27.
DOI: 10.1016/j.jaci.2017.09.029
Abstrakt: Background: In cross-sectional studies triclosan and parabens, ubiquitous ingredients in personal care and other products, are associated with allergic disease.
Objectives: We investigated the association between prenatal and early-life triclosan and paraben exposure and childhood allergic disease in a prospective longitudinal study.
Methods: Subjects were enrollees in the Vitamin D Antenatal Asthma Reduction Trial. Triclosan, methyl paraben, and propyl paraben concentrations were quantified in maternal plasma samples pooled from the first and third trimesters and urine samples from children at age 3 or 4 years. Outcomes were parental report of physician-diagnosed asthma or recurrent wheezing and allergic sensitization to food or environmental antigens based on serum specific IgE levels at age 3 years in high-risk children.
Results: The analysis included 467 mother-child pairs. Overall, there were no statistically significant associations of maternal plasma or child urine triclosan or paraben concentrations with asthma or recurrent wheeze or food or environmental sensitization at age 3 years. A trend toward an inverse association between triclosan and paraben exposure and allergic sensitization was observed. There was evidence of effect measure modification by sex, with higher odds of environmental sensitization associated with increasing paraben concentrations in male compared with female subjects.
Conclusions: We did not identify a consistent association between prenatal and early-life triclosan or paraben concentrations and childhood asthma, recurrent wheeze, or allergic sensitization in the overall study population. The differential effects of triclosan or paraben exposure on allergic sensitization by sex observed in this study warrant further exploration.
(Copyright © 2017 American Academy of Allergy, Asthma & Immunology. All rights reserved.)
Databáze: MEDLINE
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