Aldehyde levels in e-cigarette aerosol: Findings from a replication study and from use of a new-generation device.

Autor: Farsalinos KE; Department of Cardiology, Onassis Cardiac Surgery Center, Sygrou 356, Kallithea 17674, Greece; Department of Pharmacy, University of Patras, Rio 26500, Greece. Electronic address: kfarsalinos@gmail.com., Kistler KA; Department of Chemistry, The Pennsylvania State University Brandywine, 25 Yearsley Mill Road, Media, PA 19063, USA., Pennington A; Enthalpy Analytical, Inc., 800 Capitola Drive, Suite 1, Durham, NC 27713, USA., Spyrou A; Department of Cardiology, Onassis Cardiac Surgery Center, Sygrou 356, Kallithea 17674, Greece., Kouretas D; Department of Biochemistry-Biotechnology, School of Health Sciences, University of Thessaly, Viopolis, Larissa, 41500, Greece., Gillman G; Enthalpy Analytical, Inc., 800 Capitola Drive, Suite 1, Durham, NC 27713, USA.
Jazyk: angličtina
Zdroj: Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2018 Jan; Vol. 111, pp. 64-70. Date of Electronic Publication: 2017 Nov 03.
DOI: 10.1016/j.fct.2017.11.002
Abstrakt: Purpose: A recent study identified high aldehyde emissions from e-cigarettes (ECs), that when converted to reasonable daily human EC liquid consumption, 5 g/day, gave formaldehyde exposure equivalent to 604-3257 tobacco cigarettes. We replicated this study and also tested a new-generation atomizer under verified realistic (no dry puff) conditions.
Design: CE4v2 atomizers were tested at 3.8 V and 4.8 V, and a Nautilus Mini atomizer was tested at 9.0 W and 13.5 W. All measurements were performed in a laboratory ISO-accredited for EC aerosol collection and aldehyde measurements.
Results: CE4v2 generated dry puffs at both voltage settings. Formaldehyde levels were >10-fold lower, acetaldehyde 6-9-fold lower and acrolein 16-26-fold lower than reported in the previous study. Nautilus Mini did not generate dry puffs, and minimal aldehydes were emitted despite >100% higher aerosol production per puff compared to CE4v2 (formaldehyde: 16.7 and 16.5 μg/g; acetaldehyde: 9.6 and 10.3 μg/g; acrolein: 8.6 and 11.7 μg/g at 9.0 W and 13.5 W, respectively). EC liquid consumption of 5 g/day reduces aldehyde exposure by 94.4-99.8% compared to smoking 20 tobacco cigarettes.
Conclusion: Checking for dry puffs is essential for EC emission testing. Under realistic conditions, new-generation ECs emit minimal aldehydes/g liquid at both low and high power. Validated methods should be used when analyzing EC aerosol.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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