The CADMUS trial - Multi-parametric ultrasound targeted biopsies compared to multi-parametric MRI targeted biopsies in the diagnosis of clinically significant prostate cancer.

Autor: Grey A; Division of Surgery and Interventional Sciences, University College London, United Kingdom. Electronic address: alistair.grey@ucl.ac.uk., Scott R; Division of Surgery and Interventional Sciences, University College London, United Kingdom., Charman S; London School of Hygiene and Tropical Medicine, United Kingdom., van der Meulen J; London School of Hygiene and Tropical Medicine, United Kingdom., Frinking P; Bracco Suisse S.A., Geneva, Switzerland., Acher P; Department of Urology, Southend University Hospital, United Kingdom., Liyanage S; Department of Radiology, Southend University Hospital, United Kingdom., Madaan S; Department of Urology, Darent Valley Hospital, United Kingdom., Constantinescu G; Department of Radiology, Darent Valley Hospital, United Kingdom., Shah B; Surgical and Interventional Trial Unit, University College London, United Kingdom., Graves CB; Surgical and Interventional Trial Unit, University College London, United Kingdom., Freeman A; Department of Pathology, University College Hospital, United Kingdom., Jameson C; Department of Pathology, University College Hospital, United Kingdom., Ramachandran N; Department of Radiology, University College Hospital, United Kingdom., Emberton M; Division of Surgery and Interventional Sciences, University College London, United Kingdom., Arya M; Division of Surgery and Interventional Sciences, University College London, United Kingdom; Department of Urology, Princess Alexandra Hospital NHS Trust, Harlow, Essex, United Kingdom., Ahmed HU; Division of Surgery, Department of Surgery and Cancer, Imperial College London, United Kingdom; Division of Surgery and Interventional Sciences, University College London, United Kingdom.
Jazyk: angličtina
Zdroj: Contemporary clinical trials [Contemp Clin Trials] 2018 Mar; Vol. 66, pp. 86-92. Date of Electronic Publication: 2017 Nov 03.
DOI: 10.1016/j.cct.2017.10.011
Abstrakt: Objective: To compare the proportion of clinically significant prostate cancers (PCa) found in lesions detected by multiparametric MRI (mpMRI) with that found in lesions detected by multiparametric ultrasound (mpUSS), in men at risk.
Patients and Methods: CADMUS (Cancer Detection by Multiparametric Ultrasound of the prostate) is a prospective, multi-centre paired cohort diagnostic utility study with built-in randomisation of order of biopsies. The trial is registered ISRCTN38541912. All patients will undergo the index test under evaluation (mpUSS±biopsies), as well as the standard test (mpMRI±biopsies). Eligible men will be those at risk of harbouring prostate cancer usually recommended for prostate biopsy, either for the first time or as a repeat, who have not had any prior treatment for prostate cancer. Men in need of repeat biopsy will include those with prior negative results but ongoing suspicion, and those with an existing prostate cancer diagnosis but a need for accurate risk stratification. Both scans will be reported blind to the results of the other and the order in which the targeted biopsies derived from the two different imaging modalities are taken will be randomised. Comparison will be drawn between biopsy results of lesions detected by mpUSS with those lesions detected by mpMRI. Agreement over position between the two imaging modalities will be studied.
Discussion: CADMUS will provide level one evidence on the performance of mpUSS derived targeted biopsies in the identification of clinically significant prostate cancer in comparison to mpMRI targeted biopsies. Recruitment is underway and expected to complete in 2018.
(Copyright © 2017 Elsevier Inc. All rights reserved.)
Databáze: MEDLINE
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