Human health risks related to the consumption of foodstuffs of animal origin contaminated by bisphenol A.
Autor: | Gorecki S; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Bemrah N; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France., Roudot AC; Laboratoire des Interactions Epithelium Neurones, Université de Bretagne Occidentale, Brest, France., Marchioni E; Chimie Analytique des Molécules Bioactives, Institut Pluridisciplinaire Hubert Curien (UMR 7178 CNRS/UDS), 74 route du Rhin, 67400 Illkirch, France., Le Bizec B; LUNAM Université, Oniris, Laboratoire d'Étude des Résidus et Contaminants dans les Aliments (LABERCA), UMR INRA 1329, F-44307, Nantes, France., Faivre F; French Ministry of Agriculture and Food - Ministère de l'Agriculture et de l'Alimentation, 78 rue de Varenne, F-75007, Paris, France., Kadawathagedara M; INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Team 'Early Origin of the Child's Health and development' (ORCHAD), Paris Descartes University, Villejuif, France., Botton J; INSERM, UMR1153 Epidemiology and Biostatistics Sorbonne Paris Cité Center (CRESS), Team 'Early Origin of the Child's Health and development' (ORCHAD), Paris Descartes University, Villejuif, France; Faculty of Pharmacy, Université, Paris-Sud, Université, Paris-Saclay, F-92296, Châtenay-Malabry, France., Rivière G; French Agency for Food, Environmental and Occupational Health & Safety, 14 rue Pierre & Marie Curie, F-94700, Maisons-Alfort, France. Electronic address: gilles.riviere@anses.fr. |
---|---|
Jazyk: | angličtina |
Zdroj: | Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association [Food Chem Toxicol] 2017 Dec; Vol. 110, pp. 333-339. Date of Electronic Publication: 2017 Oct 28. |
DOI: | 10.1016/j.fct.2017.10.045 |
Abstrakt: | Bisphenol A (BPA) is used in a wide variety of products and objects for consumers use (digital media such as CD's and DVD's, sport equipment, food and beverage containers, medical equipment). For humans, the main route of exposure to BPA is food. Based on previous estimates, almost 20% of the dietary exposure to BPA in the French population would be from food of animal origin. However, due to the use of composite samples, the source of the contamination had not been identified. Therefore, 322 individual samples of non-canned foods of animal origin were collected with the objectives of first updating the estimation of the exposure of the French population and second identifying the source of contamination of these foodstuffs using a specific analytical method. Compared to previous estimates in France, a decline in the contamination of the samples was observed, in particular with regard to meat. The estimated mean dietary exposures ranged from 0.048 to 0.050 μg (kg bw) -1 d -1 for 3-17 year children and adolescents, from 0.034 to 0.035 μg (kg bw) -1 d -1 for adults and from 0.047 to 0.049 μg (kg bw) -1 d -1 for pregnant women. The contribution of meat to total dietary exposure of pregnant women, adults and children was up to three times lower than the previous estimates. Despite this downward trend in contamination, the toxicological values were observed to have been exceeded for the population of pregnant women. With the aim of acquiring more knowledge about the origin the potential source(s) of contamination of non-canned foods of animal origin, a specific analytical method was developed to directly identify and quantify the presence of conjugated BPA (BPA-monoglucuronide, BPA-diglucuronide and sulphate forms) in 50 samples. No conjugated forms of BPAs were detected in the analysed samples, indicating clearly that BPA content in animal food was not due to metabolism but arise post mortem in food. This contamination may occur during food production. However, despite extensive sampling performed in several different shops (butcheries, supermarkets …. ) and in different conditions (fresh, prepared, frozen …), the source(s) of the contamination could not be specifically identified. (Copyright © 2017 Elsevier Ltd. All rights reserved.) |
Databáze: | MEDLINE |
Externí odkaz: |