Leukocyte telomere length variation in different stages of schizophrenia.

Autor: Maurya PK; Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Amity Institute of Biotechnology, Amity University Uttar Pradesh, Noida, India., Rizzo LB; Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Research Group on Behavioural and Molecular Neuroscience of Bipolar Disorder, São Paulo, Brazil., Xavier G; Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Departament of Morphology and Genetics, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil., Tempaku PF; Departament of Psychobiology, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil., Ota VK; Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Departament of Morphology and Genetics, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil., Santoro ML; Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Departament of Morphology and Genetics, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil., Spíndola LM; Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Departament of Morphology and Genetics, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil., Moretti PS; Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil; Departament of Morphology and Genetics, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil., Mazzotti DR; Center for Applied Genomics, The Children's Hospital of Philadelphia, Philadelphia, United States., Gadelha A; Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil., Gouvea ES; Department of Psychiatry, Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil., Noto C; Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil., Maes M; Graduation Program in Health Sciences, Universidade Estadual de Londrina, Londrina, PR, Brazil; Department of Psychiatry, Chulalongkorn University, Bangkok, Thailand., Cordeiro Q; Department of Psychiatry, Santa Casa de Misericórdia de São Paulo, São Paulo, Brazil., Bressan RA; Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil., Brietzke E; Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Research Group on Behavioural and Molecular Neuroscience of Bipolar Disorder, São Paulo, Brazil; Program for Recognition and Intervention in Individuals in At-Risk Mental States (PRISMA), São Paulo, Brazil., Belangero SI; Interdisciplinary Laboratory for Clinical Neuroscience (LiNC), Universidade Federal de São Paulo - UNIFESP, São Paulo, Brazil; Departament of Morphology and Genetics, Universidade Federal de São Paulo (Unifesp), São Paulo, Brazil. Electronic address: sinbelangero@gmail.com.
Jazyk: angličtina
Zdroj: Journal of psychiatric research [J Psychiatr Res] 2018 Jan; Vol. 96, pp. 218-223. Date of Electronic Publication: 2017 Oct 21.
DOI: 10.1016/j.jpsychires.2017.10.016
Abstrakt: Recent research has demonstrated that telomere maintenance might be a key integrating point for the cumulative effect of genetic and environmental factors in patients with first-episode psychosis (FEP) and schizophrenia (SCZ). Eighty-one participants with antipsychotic-naïve FEP, 173 with SCZ and 438 HC were enrolled in this study. Psychiatric diagnosis was assessed using the Semi-Structured Clinical Interview for DSM-IV Axis-I (SCID-I). The Positive and Negative Syndrome Scale (PANSS), Young Mania Rating Scale (YMRS) and Calgary Depression Scale for Schizophrenia (CDSS) were used to measure symptoms severity. Telomere length (TL) was determined using a multiplex qPCR assay. After adjustment for age, years of education, and smoking status, we found that patients with SCZ had longer TL (relative ratio (RR) = 1.08) than the HC group (RR = 1.00, Wald χ 2  = 12.48, p = 0.002). Further, non-remitted SCZ patients presented longer TL (RR = 1.00) compared to remitted SCZ (RR = 0.88, Wald χ 2  = 7.20, p = 0.007). TL in patients also correlated to psychopathology assessment in terms of total (p = 0.003) and positive PANSS scores (p = 0.001). No correlation with negative PANSS, YMRS, and CDSS or effects of medication was found on TL. Although the exact pathways underlying longer TL in SCZ patients remain unclear, these findings raise more questions than answers and suggest that TL may be of immense value on SCZ progression. Further studies are required to investigate the association of TL in FEP and SCZ.
(Copyright © 2017 Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
Externí odkaz: