Long-term course of precancerous lesions arising in patients with gastric MALT lymphoma.

Autor: Rentien AL; Department of Gastroenterology, Henri Mondor University Hospital, APHP, Creteil F-94010, France; Paris Est-Creteil University (UPEC), Creteil F-94010, France; EC2M3-EA7375 Unit, Creteil, France., Lévy M; Department of Gastroenterology, Henri Mondor University Hospital, APHP, Creteil F-94010, France., Copie-Bergman C; Paris Est-Creteil University (UPEC), Creteil F-94010, France; Department of Pathology, Henri Mondor University Hospital, APHP, Creteil F-94010, France; Unit UMR-S 955, INSERM, Creteil F-94010, France., Gagniere C; Department of Gastroenterology, Henri Mondor University Hospital, APHP, Creteil F-94010, France; Paris Est-Creteil University (UPEC), Creteil F-94010, France; EC2M3-EA7375 Unit, Creteil, France., Dupuis J; Lymphoid Malignancies Unit, Henri Mondor University Hospital, APHP, Creteil F-94010, France., Le Baleur Y; Department of Gastroenterology, Henri Mondor University Hospital, APHP, Creteil F-94010, France., Belhadj K; Lymphoid Malignancies Unit, Henri Mondor University Hospital, APHP, Creteil F-94010, France., Sobhani I; Department of Gastroenterology, Henri Mondor University Hospital, APHP, Creteil F-94010, France., Haioun C; Paris Est-Creteil University (UPEC), Creteil F-94010, France; Unit UMR-S 955, INSERM, Creteil F-94010, France; Lymphoid Malignancies Unit, Henri Mondor University Hospital, APHP, Creteil F-94010, France., Delchier JC; Department of Gastroenterology, Henri Mondor University Hospital, APHP, Creteil F-94010, France; Paris Est-Creteil University (UPEC), Creteil F-94010, France., Amiot A; Department of Gastroenterology, Henri Mondor University Hospital, APHP, Creteil F-94010, France; Paris Est-Creteil University (UPEC), Creteil F-94010, France; EC2M3-EA7375 Unit, Creteil, France. Electronic address: aurelien.amiot@hmn.aphp.fr.
Jazyk: angličtina
Zdroj: Digestive and liver disease : official journal of the Italian Society of Gastroenterology and the Italian Association for the Study of the Liver [Dig Liver Dis] 2018 Feb; Vol. 50 (2), pp. 181-188. Date of Electronic Publication: 2017 Oct 27.
DOI: 10.1016/j.dld.2017.10.014
Abstrakt: Background and Aims: To evaluate the prevalence and the long-term course of gastric precancerous lesions in patients with GML.
Patients and Methods: In this retrospective single-centre study, we included 179 patients with GML, 70 with gastric diffuse large B-cell lymphoma (GDLBCL) and 152 with Helicobacter pylori-associated gastritis (HpG), from January 1995 to January 2014. The presence of atrophic gastritis, intestinal metaplasia and neoplastic lesion has been assessed at baseline and during follow-up.
Results: Atrophic gastritis was more frequent in the GML group whereas there was also a trend for intestinal metaplasia and gastric dysplasia. In patients with GML, atrophic gastritis, intestinal metaplasia and gastric dysplasia were more frequent in the GML area than in other part of the stomach. During follow-up, the prevalence of atrophic gastritis remained stable overtime whereas intestinal metaplasia and dysplasia tend to increase overtime. In multivariate analysis, the occurrence of dysplasia or carcinoma was associated with the presence of intestinal metaplasia at baseline and male gender.
Conclusion: GML is associated with gastric precancerous lesion to a higher extent than GDLBCL and HpG. Those precancerous lesions do not regress despite achievement of complete remission of GML and tend to increase overtime.
(Copyright © 2017 Editrice Gastroenterologica Italiana S.r.l. Published by Elsevier Ltd. All rights reserved.)
Databáze: MEDLINE
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