Low-molecular-weight compounds with anticoagulant activity from the scorpion Heterometrus laoticus venom.

Autor:	Thien TV; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam.; Graduate University of Science and Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam., Anh HN; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam., Trang NTT; Faculty of Pharmacy, Nguyen Tat Thanh University, Ho Chi Minh City, Vietnam., Trung PV; Istitute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam., Khoa NC; Institute of Applied Materials Science, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam., Osipov AV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia., Dubovskii PV; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia., Ivanov IA; Istitute of Chemical Technology, Vietnam Academy of Science and Technology, Ho Chi Minh City, Vietnam., Arseniev AS; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia., Tsetlin VI; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia., Utkin YN; Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry, Russian Academy of Sciences, Moscow, 117997, Russia. utkin@mx.ibch.ru.
Jazyk:	angličtina
Zdroj:	Doklady. Biochemistry and biophysics [Dokl Biochem Biophys] 2017 Sep; Vol. 476 (1), pp. 316-319. Date of Electronic Publication: 2017 Nov 04.
DOI:	10.1134/S1607672917050052
Abstrakt:	Low-molecular-weight compounds with anticoagulant activity were isolated from the scorpion Heterometrus laoticus venom. The determination of the structure of the isolated compounds by nuclear magnetic resonance and mass spectrometry showed that one of the isolated compounds is adenosine, and the other two are dipeptides leucyl-tryptophan and isoleucyl-tryptophan. The anticoagulant properties of adenosine, which is an inhibitor of platelet aggregation, is well known, but its presence in scorpion venom is shown for the first time. The ability of leucyl-tryptophan and isoleucyl-tryptophan to slow down blood clotting and their presence in scorpion venom are also established for the first time.
Databáze:	MEDLINE
Externí odkaz:	Zobrazit plný text záznamu Plný text ve formátu PDF