Subtle metabolic alterations in adolescents with obesity and polycystic ovarian syndrome.

Autor:	Vital-Reyes VS; Departamento de Biología de la Reproducción y Gineco-endocrinología, Unidad Médica de Alta Especialidad (UMAE) Hospital de Ginecología y Obstetricia 3 Dr. Víctor Manuel Espinoza de los Reyes Sánchez, Centro Médico Nacional La Raza, Instituto Mexicano del Seguro Social (IMSS)., Lopez-Alarcón MG; Unidad de Investigación Médica en Nutrición Humana, UMAE Hospital de Pediatría, Centro Médico Nacional Siglo XXI, IMSS., Inda-Icaza P; Escuela de Nutrición, Universidad Anáhuac Campus Norte, Ciudad de México., Márquez-Maldonado C; Escuela de Nutrición, Universidad Anáhuac Campus Norte, Ciudad de México.
Jazyk:	Spanish; Castilian
Zdroj:	Gaceta medica de Mexico [Gac Med Mex] 2017; Vol. 153 (Supl. 2), pp. S34-S41.
DOI:	10.24875/GMM.M17000005
Abstrakt:	Objective: To evaluate the frequency of some subtle metabolic alterations in a group of adolescents with obesity and polycystic ovary syndrome (PCOS). Materials and Methods: A cross-sectional, comparative study was conducted in a group of adolescents with obesity, and characterized as with or without PCOS according with the Rotterdam Consensus. Medical history, anthropometry, gynecologic pelvic ultrasound (to evaluate ovarian volumes, number of antral follicles and endometrial width), as well as serum glucose, insulin, lipoproteins, interleukin-6, tumor necrosis factor alpha, total testosterone, dehydroepiandrosterone, sexual hormones binding globulin, leptin, adiponectin and insulin-like growth factor 1, the free-androgen index, free and available testosterone, and homeostatic model assessment index were calculated. For statistics, mean and standard deviation, or median and ranges were used for description as appropriate. Likewise, Student t-test or Mann-Whitney test were used for comparisons. Results: From a sample of 180 adolescents, 47 attached to selection criteria. Mean age was 13.5 year and Z-score 2.5. Eighty percent of adolescents presented central distribution of body fat and 95% hyperinsulinemia. The more frequent dyslipidemias were hypertriglyceridemia in 57% and hypercholesterolemia in 12.8%; 25.5% of adolescents presented two out of three criteria for polycystic ovary syndrome (PCOS). Body mass index and insulin were correlated with free testosterone, but the multivariate analysis demonstrated that the magnitude of the association was significantly higher in SOP patients. Conclusions: The metabolic alterations detected in obese adolescents with SOP suggest that the clinical manifestations that accompany the syndrome characterize the PCOS as a metabolic disease, which carry important health risks at short, medium and long term. Therefore, they merit intervening actions to prevent, diagnose and provide timing treatment in order to limit the damage in the course of the natural history of PCOS. (Copyright: © 2017 SecretarÍa de Salud)
Databáze:	MEDLINE
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