Failed Recovery of Glycemic Control and Myofibrillar Protein Synthesis With 2 wk of Physical Inactivity in Overweight, Prediabetic Older Adults.

Autor:	McGlory C; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada., von Allmen MT; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada., Stokes T; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada., Morton RW; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada., Hector AJ; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada., Lago BA; Michael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Raphenya AR; Michael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Smith BK; Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, Canada., McArthur AG; Michael G. DeGroote Institute for Infectious Disease Research and the Department of Biochemistry and Biomedical Sciences, McMaster University, Hamilton, Ontario, Canada., Steinberg GR; Division of Endocrinology and Metabolism, McMaster University, Hamilton, Ontario, Canada.; Department of Biochemistry, McMaster University, Hamilton, Ontario, Canada., Baker SK; Division of Physical Medicine and Rehabilitation, Department of Medicine, McMaster University, Hamilton, Ontario, Canada., Phillips SM; Department of Kinesiology, McMaster University, Hamilton, Ontario, Canada.
Jazyk:	angličtina
Zdroj:	The journals of gerontology. Series A, Biological sciences and medical sciences [J Gerontol A Biol Sci Med Sci] 2018 Jul 09; Vol. 73 (8), pp. 1070-1077.
DOI:	10.1093/gerona/glx203
Abstrakt:	Background: Physical inactivity impairs insulin sensitivity, which is exacerbated with aging. We examined the impact of 2 wk of acute inactivity and recovery on glycemic control, and integrated rates of muscle protein synthesis in older men and women. Methods: Twenty-two overweight, prediabetic older adults (12 men, 10 women, 69 ± 4 y) undertook 7 d of habitual activity (baseline; BL), step reduction (SR; <1,000 steps.d-1 for 14 d), followed by 14 d of recovery (RC). An oral glucose tolerance test was used to assess glycemic control and deuterated water ingestion to measure integrated rates of muscle protein synthesis. Results: Daily step count was reduced (all p < .05) from BL at SR (7362 ± 3294 to 991 ± 97) and returned to BL levels at RC (7117 ± 3819). Homeostasis model assessment-insulin resistance increased from BL to SR and Matsuda insulin sensitivity index decreased and did not return to BL in RC. Glucose and insulin area under the curve were elevated from BL to SR and did not recover in RC. Integrated muscle protein synthesis was reduced during SR and did not return to BL in RC. Conclusions: Our findings demonstrate that 2 wk of SR leads to lowered rates of muscle protein synthesis and a worsening of glycemic control that unlike younger adults is not recovered during return to normal activity in overweight, prediabetic elderly humans. Clinical Trials Registration: ClinicalTrials.gov identifier: NCT03039556.
Databáze:	MEDLINE
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