Double versus single intensive phototherapy with LEDs in treatment of neonatal hyperbilirubinemia.

Autor: Donneborg ML; Department of Pediatrics, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark., Vandborg PK; Department of Pediatrics, Aalborg University Hospital, Aalborg, Denmark., Hansen BM; Department of Pediatrics, Herlev Hospital, Copenhagen, Denmark., Rodrigo-Domingo M; Department of Research, Education and Innovation, Aalborg University Hospital, Aalborg, Denmark., Ebbesen F; Department of Pediatrics, Aalborg University Hospital, Aalborg, Denmark.; Department of Clinical Medicine, Aalborg University, Aalborg, Denmark.
Jazyk: angličtina
Zdroj: Journal of perinatology : official journal of the California Perinatal Association [J Perinatol] 2018 Feb; Vol. 38 (2), pp. 154-158. Date of Electronic Publication: 2017 Nov 02.
DOI: 10.1038/jp.2017.167
Abstrakt: Objective: We investigate whether double phototherapy reduces total serum bilirubin concentration faster than single light during intensive phototherapy with high levels of irradiance using light-emitting diodes.
Study Design: Eighty-three infants with gestational age ⩾33 weeks and uncomplicated hyperbilirubinemia were randomized to either double (n=41) or single phototherapy (n=42) for 24 h. The mean irradiance was 64.8 μW cm -2  nm -1 from above and 39 μW cm -2  nm -1 from below.
Results: The percentage decreases of total serum bilirubin after 12 h of double vs single phototherapy were (mean (95% confidence interval (CI))) 39% (37 to 42) vs 30% (27 to 32), respectively (P<0.001). After 24 h, the decreases were 58% (56 to 61) vs 47% (44 to 50), respectively (P<0.001). The results were still significant after adjustment for confounding. The only side effect was loose stools.
Conclusion: Even with intensive phototherapy increasing spectral power by increasing the irradiated body surface area, the efficacy of phototherapy is improved.
Databáze: MEDLINE
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