[Quality evaluation of Gualou Guizhi decoction based on chemical compositions and biological effects].

Autor: Li H; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China., Qiao LF; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China., Zhang YQ; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China., Xu W; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China., Xu W; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China., Chu KD; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China., Lin Y; College of Pharmacy, Fujian University of Traditional Chinese Medicine, Fuzhou 350122, China.
Jazyk: čínština
Zdroj: Zhongguo Zhong yao za zhi = Zhongguo zhongyao zazhi = China journal of Chinese materia medica [Zhongguo Zhong Yao Za Zhi] 2017 May; Vol. 42 (10), pp. 1877-1882.
DOI: 10.19540/j.cnki.cjcmm.20170223.002
Abstrakt: The paper was aimed to establish a quality evaluation model for Gualou Guizhi decoction based on the chemical compositions and biological effects. Ultra high performance liquid chromatograph-mass spectrometer was used to analyze and determine 24 kinds of chemical compositions in Gualou Guizhi decoction, and then, biological activity effect was quantitatively assessed in a zebrafish neuronal injury model which was induced by mycophenolate mofetil (MMF). As a result, the established method for quality evaluation of Gualou Guizhi decoction based on the chemical compositions and biological effects is feasible, stable and reliable, which can provide reference for quality control of compound Chinese medicines.
Competing Interests: The authors of this article and the planning committee members and staff have no relevant financial relationships with commercial interests to disclose.
(Copyright© by the Chinese Pharmaceutical Association.)
Databáze: MEDLINE
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