Calciphylaxis with pseudoxanthoma elasticum-like changes: A case series.

Autor: Penn LA; The Ronald O. Perelman Department of Dermatology, Section of Dermatopathology, New York University, New York, New York., Brinster N; The Ronald O. Perelman Department of Dermatology, Section of Dermatopathology, New York University, New York, New York.
Jazyk: angličtina
Zdroj: Journal of cutaneous pathology [J Cutan Pathol] 2018 Feb; Vol. 45 (2), pp. 118-121. Date of Electronic Publication: 2017 Dec 12.
DOI: 10.1111/cup.13075
Abstrakt: Background: Calciphylaxis and pseudoxanthoma elasticum (PXE) are rare, clinically distinct disorders that share a common feature of cutaneous calcification and that vary widely in their cutaneous presentation.
Methods: We conducted a descriptive, retrospective review of biopsy specimens collected over a 2-year period. Only specimens with a histologic and clinical diagnosis of calciphylaxis were included in the review. Specimens were then histologically examined for features of PXE in the dermis and/or subcutaneous fat, utilizing hematoxylin and eosin staining. Von Kossa and Verhoeff-Van Gieson special stains were also performed to examine calcification and elastic fibers, respectively.
Results: We reviewed 13 biopsy specimens from 9 patients with known clinical and histologic evidence of calciphylaxis, both uremic and non-uremic types. Upon re-examination, we found that 46.2% (n = 6/13) of the specimens showed concomitant PXE-like changes uniquely localized to the subcutaneous fat.
Conclusion: The presence of PXE-like changes in the subcutis may heighten suspicion for a diagnosis of calciphylaxis in the appropriate clinical setting and be helpful when classic histologic features are subtle or absent.
(© 2017 John Wiley & Sons A/S. Published by John Wiley & Sons Ltd.)
Databáze: MEDLINE
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