Immunomodulatory Potential of the Polysaccharide-Rich Extract from Edible Cyanobacterium Nostoc commune .

Autor: Liao HF; Department of Biochemical Science and Technology, National Chiayi University, 300 Syuefu Road, Chiayi City 60004, Taiwan. liaohf@mail.ncyu.edu.tw., Wu TJ; Department of Biochemical Science and Technology, National Chiayi University, 300 Syuefu Road, Chiayi City 60004, Taiwan. s0910324@mail.ncyu.edu.tw.; Department of Applied Chemistry, National Chiayi University, 300 Syuefu Road, Chiayi City 60004, Taiwan. s0910324@mail.ncyu.edu.tw., Tai JL; Sung Yu Technology Co., Ltd., 7 Dali Road, Rende District, Tainan City 71754, Taiwan. tai@sung-yu.com.tw., Chi MC; Department of Applied Chemistry, National Chiayi University, 300 Syuefu Road, Chiayi City 60004, Taiwan. s0910324@mail.ncyu.edu.tw., Lin LL; Department of Applied Chemistry, National Chiayi University, 300 Syuefu Road, Chiayi City 60004, Taiwan. llin@mail.ncyu.edu.tw.
Jazyk: angličtina
Zdroj: Medical sciences (Basel, Switzerland) [Med Sci (Basel)] 2015 Nov 04; Vol. 3 (4), pp. 112-123. Date of Electronic Publication: 2015 Nov 04.
DOI: 10.3390/medsci3040112
Abstrakt: A dry sample of Nostoc commune from an organic farm in Pingtung city (Taiwan) was used to prepare polysaccharide-rich (NCPS) extract. The conditioned medium (CM) from NCPS-treated human peripheral blood (PB)-mononuclear cells (MNC) effectively inhibited the growth of human leukemic U937 cells and triggered differentiation of U937 monoblast cells into monocytic/macrophagic lines. Cytokine levels in MNC-CMs showed upregulation of granulocyte/macrophage-colony stimulatory factor and IL-1β and downregulation of IL-6 and IL-17 upon treatment with NCPS. Moreover, murine macrophage RAW264.7 cells treated with NCPS exhibited the stimulatory effects of nitric oxide and superoxide secretion, indicating that NCPS might activate the immunity of macrophages. Collectively, the present study demonstrates that NCPS from N. commune could be potentially used for macrophage activation and consequently inhibited the leukemic cell growth and induced monocytic/macrophagic differentiation.
Databáze: MEDLINE
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