ScvO 2 changes after red-blood-cell transfusion for anaemia in cardiothoracic and vascular ICU patients: an observational study.

Autor: Zeroual N; Département d'anesthésie réanimation Arnaud de Villeneuve, Centre Hospitalier Régional et Universitaire, Montpellier, France., Samarani G; Département d'anesthésie réanimation Arnaud de Villeneuve, Centre Hospitalier Régional et Universitaire, Montpellier, France., Gallais J; Département d'anesthésie réanimation Arnaud de Villeneuve, Centre Hospitalier Régional et Universitaire, Montpellier, France., Culas G; Département d'anesthésie réanimation Arnaud de Villeneuve, Centre Hospitalier Régional et Universitaire, Montpellier, France., Saour M; Département d'anesthésie réanimation Arnaud de Villeneuve, Centre Hospitalier Régional et Universitaire, Montpellier, France., Mourad M; Département d'anesthésie réanimation Arnaud de Villeneuve, Centre Hospitalier Régional et Universitaire, Montpellier, France., Gaudard P; Département d'anesthésie réanimation Arnaud de Villeneuve, Centre Hospitalier Régional et Universitaire, Montpellier, France.; PhyMedExp, INSERM U1046, University of Montpellier, Montpellier, France., Colson PH; Département d'anesthésie réanimation Arnaud de Villeneuve, Centre Hospitalier Régional et Universitaire, Montpellier, France.; Institut de Génomique Fonctionnelle Endocrinology Department, CNRS UMR 5203, INSERM U1191, University of Montpellier, Montpellier, France.
Jazyk: angličtina
Zdroj: Vox sanguinis [Vox Sang] 2018 Feb; Vol. 113 (2), pp. 136-142. Date of Electronic Publication: 2017 Oct 29.
DOI: 10.1111/vox.12610
Abstrakt: Background and Objectives: Haemoglobin threshold for transfusion has been significantly decreased, but haemoglobin plasma concentration may not be sufficient to assess the need of red-blood-cell (RBC) transfusion. Central venous oxygen saturation (ScvO 2 ) is a clue of metabolic matching between O 2 transport and consumption, which could help to assess when transfusion is appropriate once anaemia has been diagnosed in ICU patients.
Materials and Methods: Adult patients admitted consecutively to a cardiothoracic and vascular ICU were included in a prospective, observational and single-centre study over a 6-month period (September 2014 to February 2015), provided they were transfused with RBC. Patients with active bleeding or in unstable condition were excluded. Haemoglobin and ScvO 2 were collected through a central venous catheter before and after transfusion. In order to identify a ScvO 2 threshold, analysis of ScvO 2 changes after transfusion was performed.
Results: Fifty-three patients received 100 RBC transfusions. Haemoglobin at the time of transfusion was 7·2 g/dl [6·8-7·7], while ScvO 2 was 66·9% [60-73]. A 5% increase in ScvO 2 after transfusion has the best specificity and positive predictive values, with a ScvO 2 threshold of 65%. After transfusion (RBC units, 2 [1-2]), ScvO 2 increased only in patients with ScvO 2 ≤65%, from 58% [53-62] to 69% [64-73] (P < 0·001).
Conclusion: In anaemic patients, RBC transfusion induced a significant increase in ScvO 2 , provided it was low before transfusion. A 65% cut-off value of ScvO 2 before transfusion showed good specificity and good positive predictive value for a 5% increase after transfusion.
(© 2017 International Society of Blood Transfusion.)
Databáze: MEDLINE
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