M protein gene (emm type) analysis of group A Streptococcus isolates recovered during an acute glomerulonephritis outbreak in northern Western Australia.

Autor: Speers DJ; Department of Microbiology, PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Hospital Avenue, Nedlands, Australia; School of Medicine and Pharmacology, University of Western Australia, Crawley, Australia. Electronic address: david.speers@health.wa.gov.au., Levy A; Department of Microbiology, PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Hospital Avenue, Nedlands, Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Australia., Gichamo A; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Australia., Eastwood A; WA Country Health Service, Kimberley Population Health Unit, Department of Health, Broome, WA, Australia., Leung MJ; Department of Microbiology, PathWest Laboratory Medicine WA, Queen Elizabeth II Medical Centre, Hospital Avenue, Nedlands, Australia; School of Pathology and Laboratory Medicine, University of Western Australia, Crawley, Australia.
Jazyk: angličtina
Zdroj: Pathology [Pathology] 2017 Dec; Vol. 49 (7), pp. 765-769. Date of Electronic Publication: 2017 Oct 24.
DOI: 10.1016/j.pathol.2017.09.001
Abstrakt: Certain M protein types of group A streptococcus (GAS) are known to cause acute post-streptococcal glomerulonephritis (APSGN). Outbreaks of APSGN can occur regularly in tropical regions but the emm types responsible are geographically and temporally diverse. GAS isolates from Western Australia (WA) were analysed for emm type and emm cluster during the period of increased APSGN activity in the tropical northern Kimberley region of WA. Although emm types 49, 75 and 108 and corresponding emm clusters E3, E6 and D4 were more common in WA during the outbreak there was no predominant circulating emm type or cluster found to correspond to the APSGN activity. This is consistent with the high diversity of GAS strains found during APSGN outbreaks in other countries. Potential vaccine coverage of the new 30-valent M-protein GAS vaccine was 70%.
(Crown Copyright © 2017. Published by Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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