| Autor: |
Quistad GB; Sandoz Crop Protection Corporation, Zoecon Research Institute, Palo Alto, CA 94303-0859., Saunders AL, Skinner WS, Collier KD, Sakai DH, Reuter CC |
| Jazyk: |
angličtina |
| Zdroj: |
Drug metabolism and disposition: the biological fate of chemicals [Drug Metab Dispos] 1988 Nov-Dec; Vol. 16 (6), pp. 818-22. |
| Abstrakt: |
Metabolism of [benzyl-14C]fluvalinate by chickens produces 3-phenoxybenzoic acid, which is further degraded by two new pathways. The first pathway involves O-dephenylation, not reported previously for related pyrethroids in birds or mammals. O-Dephenylation is a major metabolic route (12% of the applied 14C). In the second pathway, 2% of the applied dose is converted into four conjugates of benzoylornithine (two with 3-hydroxybenzoic and two with 3-phenoxybenzoic acids). The predominant conjugate with benzoylornithine is N2-(3-hydroxybenzoyl)-N5-benzoylornithine. |
| Databáze: |
MEDLINE |
| Externí odkaz: |
|
