Hypolipidemic effect of mannans from C. albicans serotypes a and B in acute hyperlipidemia in mice.

Autor: Korolenko TA; Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia. Electronic address: t.a.korolenko@physiol.ru., Johnston TP; Division of Pharmaceutical Sciences, University of Missouri-Kansas City, Kansas City, MO, United States. Electronic address: johnstont@umkc.edu., Machova E; Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Bratislava, Slovakia. Electronic address: chememch@savba.sk., Bgatova NP; Scientific Institute of Clinical and Experimental Lymphology-filial of the Institute of Cytology and Genetic Siberian Branch of Russian Academy of Science, Novosibirsk, Russia. Electronic address: n_bgatova@ngs.ru., Lykov AP; Scientific Institute of Clinical and Experimental Lymphology-filial of the Institute of Cytology and Genetic Siberian Branch of Russian Academy of Science, Novosibirsk, Russia. Electronic address: aplykov@mail.ru., Goncharova NV; Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia. Electronic address: natalya15.ru@rambler.ru., Nescakova Z; Institute of Chemistry, Center for Glycomics, Slovak Academy of Sciences, Bratislava, Slovakia. Electronic address: chemnesc@savba.sk., Shintyapina AB; Institute of Molecular Biology and Biophysics, Novosibirsk, Russia. Electronic address: shintyapina@yandex.ru., Maiborodin IV; The Institute of Chemical Biology and Fundamental Medicine of the Siberian Branch of the Russian Academy of Sciences, Novosibirsk, Russia. Electronic address: imai@mail.ru., Karmatskikh OL; Scientific Research Institute of Physiology and Basic Medicine, Novosibirsk, Russia. Electronic address: t.a.korolenko@physiol.ru.
Jazyk: angličtina
Zdroj: International journal of biological macromolecules [Int J Biol Macromol] 2018 Feb; Vol. 107 (Pt B), pp. 2385-2394. Date of Electronic Publication: 2017 Oct 23.
DOI: 10.1016/j.ijbiomac.2017.10.111
Abstrakt: Mannans, which are biological macromolecules of polysaccharide origin and function as immunomodulators, have been shown to stimulate macrophages in vivo by interaction with the mannose receptor. Thus, they can be used to stimulate macrophages in order to effectively remove circulating atherogenic lipoproteins. Our primary aim was to evaluate the hypolipidemic potential of mannans from C. albicans serotype A (mannan A) and serotype B (mannan B) in a murine model of hyperlipidemia. Mannan A and mannan B were shown to significantly (p<0.05) stimulate both the proliferation (p <0.05) and nitric oxide production of murine peritoneal macrophages in vitro. Pre-treatment of CBA/Lac mice with mannan A prior to induction of hyperlipidemia significantly (p<0.001) reduced serum atherogenic LDL-cholesterol, total cholesterol, and triglycerides. Mannan B exhibited a similar, but more potent, hypolipidemic effect. Electron microscopic analysis of liver revealed a significant (p<0.001) decrease in the volume of lipid droplets when hyperlipidemic mice were pretreated by both mannans. In conclusion, our findings would suggest that both polysaccharide-based biological macromolecules evaluated in the present study, specifically, the natural immunomodulators (mannans A and B), appeared to function as effective lipid-lowering macromolecules, which could potentially serve as adjunct therapy to more conventional hypolipidemic medications such as a statin drug.
(Copyright © 2017 Elsevier B.V. All rights reserved.)
Databáze: MEDLINE
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