Prevalence of peripheral artery disease (PAD) and factors associated: An epidemiological analysis from the population-based Screening PRE-diabetes and type 2 DIAbetes (SPREDIA-2) study.

Autor: Cornejo Del Río V; Hospital Carlos III, Madrid, Spain.; Grupo de Investigación en cuidados IdIPAZ, Hospital La Paz, Madrid, Spain., Mostaza J; Hospital Carlos III, Madrid, Spain., Lahoz C; Hospital Carlos III, Madrid, Spain., Sánchez-Arroyo V; Hospital Carlos III, Madrid, Spain., Sabín C; Hospital Carlos III, Madrid, Spain., López S; Hospital Carlos III, Madrid, Spain., Patrón P; Hospital Carlos III, Madrid, Spain., Fernández-García P; Hospital Carlos III, Madrid, Spain., Fernández-Puntero B; Hospital Carlos III, Madrid, Spain., Vicent D; Hospital Carlos III, Madrid, Spain.; Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, Spain., Montesano-Sánchez L; Hospital de Fuenlabrada, Madrid, Spain., García-Iglesias F; Hospital Carlos III, Madrid, Spain., González-Alegre T; Hospital Carlos III, Madrid, Spain., Estirado E; Hospital Carlos III, Madrid, Spain., Laguna F; Hospital Carlos III, Madrid, Spain., de Burgos-Lunar C; Dirección General de Salud Pública, Subdirección de Promoción, Prevención y Educación de la Salud, Consejería de Sanidad, Madrid, Spain.; Red de Investigación en servicios de salud en enfermedades crónicas (REDISSEC), Madrid, Spain., Gómez-Campelo P; Instituto de Investigación Sanitaria del Hospital Universitario La Paz (IdiPAZ), Madrid, Spain.; Plataforma de Apoyo al Investigador Novel, IdiPAZ, Madrid, Spain., Abanades-Herranz JC; Centro de Salud Monóvar, Madrid, Spain., de Miguel-Yanes JM; Hospital Gregorio Marañón, Madrid, Spain., Salinero-Fort MA; Red de Investigación en servicios de salud en enfermedades crónicas (REDISSEC), Madrid, Spain.; Subdirección General de Investigación Sanitaria, Consejería de Sanidad, Madrid, Spain.
Jazyk: angličtina
Zdroj: PloS one [PLoS One] 2017 Oct 26; Vol. 12 (10), pp. e0186220. Date of Electronic Publication: 2017 Oct 26 (Print Publication: 2017).
DOI: 10.1371/journal.pone.0186220
Abstrakt: Aim: To describe the prevalence of Peripheral Artery Disease (PAD) in a random population sample and to evaluate its relationship with Mediterranean diet and with other potential cardiovascular risk factors such as serum uric acid and pulse pressure in individuals ranged 45 to 74 years.
Methods: Cross-sectional analysis of 1568 subjects (mean age 6.5 years, 43% males), randomly selected from the population. A fasting blood sample was obtained to determine glucose, lipids, and HbA1C levels. An oral glucose tolerance test was performed in non-diabetic subjects. PAD was evaluated by ankle-brachial index and/or having a prior diagnosis.
Results: PAD prevalence was 3.81% (95% CI, 2.97-4.87) for all participants. In men, PAD prevalence was significantly higher than in women [5.17% (95% CI, 3.74-7.11) vs. 2.78% (95% CI, 1.89-4.07); p = 0.014]. Serum uric acid in the upper quartile was associated with the highest odds ratio (OR) of PAD (for uric acid > 6.1 mg/dl, OR = 4.31; 95% CI, 1.49-12.44). The remaining variables more strongly associated with PAD were: Heart rate >90 bpm (OR = 4.16; 95%CI, 1.62-10.65), pulse pressure in the upper quartile (≥ 54 mmHg) (OR = 3.82; 95%CI, 1.50-9.71), adherence to Mediterranean diet (OR = 2.73; 95% CI, 1.48-5.04), and former smoker status (OR = 2.04; 95%CI, 1.00-4.16).
Conclusions: Our results show the existence of a low prevalence of peripheral artery disease in a population aged 45-74 years. Serum uric acid, pulse pressure and heart rate >90 bpm were strongly associated with peripheral artery disease. The direct association between Mediterranean diet and peripheral artery disease that we have found should be evaluated through a follow-up study under clinical practice conditions.
Databáze: MEDLINE
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