| Autor: |
Cherdantseva TM; Altai State Medical University, the Ministry of Health of the Russian Federation, Barnaul, Russia., Bobrov IP; Altai State Medical University, the Ministry of Health of the Russian Federation, Barnaul, Russia.; Altai Affiliated Department, N. N. Blokhin Russian Oncological Center, the Ministry of Health of the Russian Federation, Barnaul, Russia., Avdalyan AM; Altai Affiliated Department, N. N. Blokhin Russian Oncological Center, the Ministry of Health of the Russian Federation, Barnaul, Russia., Klimachev VV; Altai State Medical University, the Ministry of Health of the Russian Federation, Barnaul, Russia., Kazartsev AV; Altai State Medical University, the Ministry of Health of the Russian Federation, Barnaul, Russia., Kryuchkova NG; Altai State Medical University, the Ministry of Health of the Russian Federation, Barnaul, Russia., Klimachev IV; Altai State Medical University, the Ministry of Health of the Russian Federation, Barnaul, Russia., Myadelets MN; Altai State Medical University, the Ministry of Health of the Russian Federation, Barnaul, Russia., Lepilov AV; Altai State Medical University, the Ministry of Health of the Russian Federation, Barnaul, Russia., Lushnikova EL; Institute of Molecular Pathology and Pathomorphology, Novosibirsk, Russia. pathol@inbox.ru., Molodykh OP; Altai State Medical University, the Ministry of Health of the Russian Federation, Barnaul, Russia. |
| Abstrakt: |
Morphofunctional activity of mast cells in renal cancer is studied on specimens from the center of the tumor, peritumorous zone (with an obligatory fragment of the pseudocapsule), and from renal tissues maximally distant from the tumor. The counts and areas of tumor cells were maximum in the peritumorous zone in comparison with intact kidney tissue and central zone of the tumor. Analysis of correlations revealed a direct correlation between the tumor cell count in the peritumorous zone and some clinical morphological parameters of the tumor (anaplasia degree, size, presence of invasion and metastases, and angiogenesis). The count of mast cells in the renal peritumorous zone inversely correlated with 5-year survival: 100% cumulative 5-year survival in patients with mast cell count <6.7±1.6 per field of view. |
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